Richard E. Wilcox

TL;DR: The bilateral adhesive removal (tactile extinction) test appears to permit the separate quantification of stimulus-directed and stimulus-independent movement asymmetries.

TL;DR: It was found that rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway showed a contralateral sensorimotor bias in response to doses of apomorphine below those necessary to produce contraversive circling, and in a second study, unilateral striatal microinjections of kainic acid were used to destroy the neurons on which the postsynaptic dopaminergic receptors are contained.

TL;DR: The present results suggest that there may be a possible reciprocal relationship between changes in DA metabolites and DA binding as a function of exercise in presenescent older rats, and that endurance training may decelerate the effects of age both on nigrostriatal dopamine neurons and on striatal D2 dopamine receptors during a portion of the lifespan.

TL;DR: A reactive capacity task which requires the animal to react with maximal speed appears to be a potentially good index of nigrostriatal dopamine integrity even when the depletion is not severe.

TL;DR: Exercise can alter the number of DA binding sites and the metabolism of DA in young adult animals, according to the relationship between steady-state levels of DA and its metabolites in striatum and the affinity and density of striatal D2 DA receptors.