R
Richard J. Colonno
Researcher at Bristol-Myers Squibb
Publications - 146
Citations - 14924
Richard J. Colonno is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Entecavir & Hepatitis B virus. The author has an hindex of 57, co-authored 141 publications receiving 14236 citations. Previous affiliations of Richard J. Colonno include Hoffmann-La Roche.
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Inhibitors of HIV-1 attachment. Part 2: an initial survey of indole substitution patterns. Bioorg Med Chem Lett
Nicholas A. Meanwell,Owen Brendan Wallace,Haiquan Fang,Henry Wang,Milind Deshpande,Tao Wang,Zhiwei Yin,Zhongxing Zhang,Bradley C. Pearce,Jennifer James,Kap-Sun Yeung,Zhilei Qiu,J. J. Kim Wright,Zheng Yang,Lisa Zadjura,Donald L. Tweedie,Suresh Yeola,Fang Zhao,Sunanda A. Ranadive,Brett A. Robinson,Yi-Fei Gong,Hwei-Gene Heidi Wang,Timothy P. Spicer,Wade S. Blair,Pei Yong Shi,Richard J. Colonno,Pin-Fang Lin +26 more
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Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-585248).
Alicia Regueiro-Ren,Qiufen M. Xue,Jacob Swidorski,Yi-Fei Gong,Marina Mathew,Dawn D. Parker,Zheng Yang,Betsy J. Eggers,Celia D’Arienzo,Yongnian Sun,Jacek Malinowski,Qi Gao,Dedong Wu,David R. Langley,Richard J. Colonno,Caly Chien,Dennis M. Grasela,Ming Zheng,Pin-Fang Lin,Nicholas A. Meanwell,John F. Kadow +20 more
TL;DR: A series of highly potent HIV-1 attachment inhibitors with 4-fluoro-6-azaindole core heterocycles that target the viral envelope protein gp120 exhibited much improved in vitro potency and pharmacokinetic properties than the previous clinical candidate BMS-488043.
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Interaction of a limited set of proteins with different mRNAs and protection of 5′-caps against pyrophosphatase digestion in initiation complexes
TL;DR: A variety of 5'-3H-methyl-labeled, oxidized viral mRNAs were used as probes for detecting in wheat germ initiation complexes proteins that interact with, and can be cross-linked to, the 5'-cap structure, and a model for cap binding protein interaction with mRNA cap during initiation of translation is suggested.
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Characterization of siamycin I, a human immunodeficiency virus fusion inhibitor
P.-F. Lin,Himadri Samanta,Bechtold Clifford M,Carol Deminie,A K Patick,M. Alam,Keith Riccardi,Ronald E. Rose,R J White,Richard J. Colonno +9 more
TL;DR: Results indicate that siamycin I interacts with the HIV envelope protein, and a comparison of the DNA sequences of the envelope genes from the resistant and parent viruses revealed a total of six amino acid changes.
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Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase.
Daniel J. Tenney,Gregory Yamanaka,S M Voss,Christopher Cianci,A. V. Tuomari,Amy K. Sheaffer,M. Alam,Richard J. Colonno +7 more
TL;DR: The results suggest that LBV-triphosphate halts HCMV DNA replication by inhibiting the viral DNA polymerase and thatLBV phosphorylation can occur in the absence of viral factors including the UL97 protein kinase, and may be effective in the treatment of GCV-resistant H CMV.