R
Richard J. Colonno
Researcher at Bristol-Myers Squibb
Publications - 146
Citations - 14924
Richard J. Colonno is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Entecavir & Hepatitis B virus. The author has an hindex of 57, co-authored 141 publications receiving 14236 citations. Previous affiliations of Richard J. Colonno include Hoffmann-La Roche.
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Journal ArticleDOI
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion.
Ronald S. Veazey,Per Johan Klasse,Susan M. Schader,Qinxue Hu,Thomas J. Ketas,Min Lu,Preston A. Marx,Jason Dufour,Richard J. Colonno,Robin J. Shattock,Martin S. Springer,John P. Moore +11 more
TL;DR: The vaginal microbicide concept using the rhesus macaque ‘high dose’ vaginal transmission model with a CCR5-receptor-using simian–human immunodeficiency virus (SHIV-162P3) and three compounds that inhibit different stages of the virus–cell attachment and entry process is evaluated.
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De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus
Guangxiang Luo,Robert K. Hamatake,Danielle M. Mathis,Jason Racela,Karen Rigat,Julie A. Lemm,Richard J. Colonno +6 more
TL;DR: It is suggested that HCV NS5B is able to initiate RNA synthesis de novo, and modification of the RNA template by the addition of the chain terminator cordycepin at the 3′ end did not affect synthesis ofThe RNA monomer but eliminated synthesis of the self-priming hairpin dimer RNA.
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Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus.
S. Innaimo,M. Seifer,Gregory S. Bisacchi,David N. Standring,Robert Zahler,Richard J. Colonno +5 more
TL;DR: Direct comparison of the antiviral activities of BMS-200475 with those of a variety of other nucleoside analogs, including lamivudine (EC50 = 116.26 nM), demonstrated the clearly superior in vitro potency of the novel carbocyclic 2'-deoxyguanosine analog.
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cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1
Joanne E. Tomassini,Donald J. Graham,Corrille M. Dewitt,Donald W. Lineberger,John A. Rodkey,Richard J. Colonno +5 more
TL;DR: Using degenerate oligonucleotides predicted from the peptide sequences, four cDNA clones are identified that encode a 3-kilobase mRNA that is nearly identical to that of the intercellular adhesion molecule 1 (ICAM-1), indicating that the two surface proteins are one and the same.
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A Dose-Ranging Study of the Efficacy and Tolerability of Entecavir in Lamivudine-refractory Chronic Hepatitis B Patients
Ting-Tsung Chang,Robert G. Gish,Stephanos J. Hadziyannis,Janusz Cianciara,Mario Rizzetto,Eugene R. Schiff,Giuseppe Pastore,Bruce R. Bacon,Thierry Poynard,Shobha Joshi,K. Klesczewski,Alexandra Thiry,Ronald E. Rose,Richard J. Colonno,R. Hindes +14 more
TL;DR: In HBeAg-positive and H beAg-negative lamivudine-refractory patients, treatment with entecavir 1.0 and 0.5 mg daily was well tolerated and resulted in significant reductions in HBV DNA levels and normalization of alanine aminotransferase levels.