R
Richard M. Edwards
Researcher at GlaxoSmithKline
Publications - 67
Citations - 2202
Richard M. Edwards is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Angiotensin II & Receptor. The author has an hindex of 26, co-authored 67 publications receiving 2150 citations.
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Journal ArticleDOI
SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist
Eliot H. Ohlstein,Ponnal Nambi,Stephen A. Douglas,Richard M. Edwards,M Gellai,A. Lago,J D Leber,Russell D. Cousins,A Gao,James S. Frazee +9 more
TL;DR: An extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist, SB 209670, has been synthesized and characterized and will be useful in characterizing and classifying the physiological and pathophysiological effects of ET.
Journal ArticleDOI
Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine.
TL;DR: A cDNA clone isolated from human small intestine and lung appeared to be an isoform of the mammalian renal type II co-transporter family and was found to be abundantly expressed in lung and, to a lesser degree, in several other tissues of epithelial origin.
Journal ArticleDOI
Renal microvascular effects of endothelin.
TL;DR: It is demonstrated that endothelin 1, 2, and 3 are potent vasoconstrictors of both the pre- and postglomerular microvasculature and may play a role in the regulation of renal hemodynamics and the response of efferent arterioles to ET-1 and norepinephrine and nicardipine or verapamil.
Journal Article
Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.
Richard M. Edwards,Nambi Aiyar,Eliot H. Ohlstein,E. F. Weidley,E. Griffin,Mildred Ezekiel,R M Keenan,Robert R. Ruffolo,Joseph Weinstock +8 more
TL;DR: The data demonstrate that SK&F 108566 is a potent, highly selective, competitive nonpeptide AII antagonist.
Journal Article
Calcitonin gene-related peptide stimulates adenylate cyclase and relaxes intracerebral arterioles.
TL;DR: It is demonstrated that CGRP stimulates adenylate cyclase activity and is a potent vasodilator of small parenchymal cerebral arterioles in vitro and may play an important role in the regulation of cerebral blood flow.