R
Richard Zhang
Researcher at Pfizer
Publications - 44
Citations - 2289
Richard Zhang is an academic researcher from Pfizer. The author has contributed to research in topics: Donepezil & Tofacitinib. The author has an hindex of 20, co-authored 44 publications receiving 2047 citations.
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Journal ArticleDOI
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD
Bengt Winblad,Knut Engedal,H. Soininen,Frans R.J. Verhey,Gunhild Waldemar,Anders Wimo,A.-L. Wetterholm,Richard Zhang,Anders Haglund,Ponni Subbiah +9 more
TL;DR: It remains puzzling to me why the investigators restricted the entry criteria and consequently selected a population that was not representative of general clinical practice when excluding patients with frequently coexisting medical conditions such as diabetes, chronic obstructive pulmonary disease, and endocrine diseases.
Journal ArticleDOI
Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial
Roy Fleischmann,Eduardo Mysler,Stephen Hall,Alan J Kivitz,Robert J. Moots,Zhen Luo,Ryan DeMasi,Koshika Soma,Richard Zhang,Liza Takiya,Svitlana Tatulych,Christopher F. Mojcik,Sriram Krishnaswami,Sujatha Menon,Josef S Smolen,Luthando Adams,Mahmood M Ally,Maria C du Plooy,Ingrid Louw,Savithree Nayiager,Christoffel B Nel,Debra Nel,Helmuth Reuter,Ahmed S Soloman,Catherine E Spargo,Maureen Rischmueller,Shunil D Sharma,Robert K Will,Peter Youssef,Caroline Arroyo,Rosario P Baes,Roger B Dulos,Llewellyn T Hao,Allan E Lanzon,Juan Javier T Lichauco,Jill H Mangubat,Edgar B Ramiterre,Bernadette Heizel M Reyes,Perry P Tan,Jung-Yoon Choe,Young Mo Kang,Seong Ryul Kwon,Sang-Heon Lee,Shin-Seok Lee,Dae-Hyun Yoo,Hsiao-Yi Lin,Shue-Fen Luo,Shih-Tzu Tsai,Wen-Chan Tsai,Jui-Cheng Tseng,Cheng-Chung C Wei,Paijit Asavatanabodee,Kanokrat Nantiruj,Surasak Nilganuwong,Parichat Uea-Areewongsa,Ljubinka Bozic Majstorovic,Suada Mulic Bacic,Anastas Batalov,Gabriela Georgieva-Slavcheva,Mariyana Mihailova,Nikolay G Nikolov,Dimitar P Penev,Yuliy A Spasov,Krasimira Stanimirova,Stoyan Todorov,Antoaneta R Toncheva,Nadezhda Yordanova,Zdenka Mosterova,Libor Novosad,Leona Prochazkova,Helena Stehlikova,Zuzana Stejfova,Natalia Kiseleva,Lea Pank,Triin Savi,Balbir-Gurman Alexandra,Howard Amital,Dror Mevorach,Itzhak A Rosner,Anna Mihailova,Evija Stumbra-Stumberga,Vida Basijokiene,Virginija Lietuvininkiene,Dalia Unikiene,Jan Brzezicki,Anna Dudek,Maria B Glowacka-Kulesz,Barbara Grabowicz-Wasko,Sabina Hajduk-Kubacka,Joanna Hilt,Pawel Hrycaj,Slawomir Jeka,Renata Kolasa,Marek Krogulec,Hanna Mastalerz,Anna Olak-Popko,Elzbieta Owczarek,Zofia Ruzga,Alina Walczak,Codrina I Ancuta,Ioan Ancuta,Andra R Balanescu,Florian Berghea,Silvia Bojin,Mihaela A Ianuli Arvunescu,Ruxandra M Ionescu,Eugenia Mociran,Mariana Pavel,Simona Rednic,Adriana Voie,Carmen M Zainea,Olga V Bugrova,Demin Aa,Olga Ershova,Inna A Gavrisheva,Diana G Krechikova,Gennady V Kuropatkin,Irina M Marusenko,Irina V Menshikova,Sergey M Noskov,A P Rebrov,Svetlana A Smakotina,Sergey Yakushin,Evgeny Zhilyaev,Juan Jose Amarelo Ramos,Francisco Javier Blanco Garcia,Antonio Fernandez Nebro,Silvia Perez Esteban,Juan Miguel Sanchez Burson,Raimon Sanmarti Sala,Sebnem Ataman,Sami Hizmetli,Omer Kuru,Karen M J Douglas,Paul Emery,Voon H Ong,Thomas P Sheeran,Rafat Y Faraawi,Clode Lessard,Carlos Abud Mendoza,Hilario Ernesto Avila-Armengol,Francisco I Avila Zapata,Fedra Irazoque-Palazuelos,Marco Antonio Maradiaga Cecena,César Pacheco-Tena,Juan C Rizo-Rodriguez,Isaura M Rodriguez-Torres,Jacob A Aelion,Barbara A Caciolo,James M Calmes,Prem Chatpar,Nimesh Dayal,Alex De Jesus,Ara Dikranian,Erdal Diri,Michael J Fairfax,Ira F Fenton,Roy Fleischmann,Norman Gaylis,Ronald L George,Dale G Halter,Paul Hernandez,Susan A Hole,Antony C Hou,John P Huff,Suzanne Kafaja,Alastair C Kennedy,Howard Kenney,Steven C. Kimmel,Brian S Kirby,Clarence W Legerton,Stephen M Lindsey,Jyothi R. Mallepalli,Steven D Mathews,Samy K Metyas,Wesley T Mizutani,Sabeen Najam,João Nascimento,Shirley W Pang,Rakesh C Patel,Jeffrey E Poiley,Carlos E Ramirez,Riteesha Reddy,Qaiser Rehman,William M Schnitz,Craig D. Scoville,William J Shergy,Joel C Silverfield,Atul Singhal,Yvonne R Smallwood-Sherrer,Suthin N Songcharoen,Michael T. Stack,William Stohl,Tien-I K Su,James Udell,Saleem Waraich,Charles E Weidmann,Nathan Wei,Craig W Wiesenhutter,Anne E Winkler,Karen E Zagar,Alberto Berman,Eduardo Mysler,Rodolfo A Pardo Hidalgo,Horacio O Venarotti,Irmgadt Annelise Goecke Sariego,Renato E Jimenez Calabresse,Juan Ignacio Vargas Ruiz-Tagle,Luis Vargas,Alfredo E Berrocal,Manuel Gustavo Leon Portocarrero,Felix Jesus,Romero Pena +212 more
TL;DR: Tofacitinib monotherapy was not shown to be non-inferior to either combination of adalimumab and methotrexate, and no new or unexpected safety issues were reported for either treatment in this study for up to 1 year.
Journal ArticleDOI
3-Year Study of Donepezil Therapy in Alzheimer’s Disease: Effects of Early and Continuous Therapy
Bengt Winblad,Anders Wimo,Knut Engedal,H. Soininen,Frans R.J. Verhey,Gunhild Waldemar,A.-L. Wetterholm,Anders Haglund,Richard Zhang,R. Schindler +9 more
TL;DR: Patients in whom the start of treatment is delayed may demonstrate slightly reduced benefits as compared with those seen in patients starting donepezil therapy early in the course of Alzheimer’s disease, and data support the long-term efficacy and safety ofdonepezil.
Journal ArticleDOI
Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioral disorders
TL;DR: The results of these analyses suggest that donepezil reduces behavioral symptoms, particularly mood disturbances and delusions, in patients with AD with relatively severe psychopathology.
Journal ArticleDOI
A multinational, randomised, 12‐week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease
Roy W. Jones,Hilkka Soininen,Klaus Hager,Dag Aarsland,Peter Passmore,Anita Murthy,Richard Zhang,Ranbir Bahra +7 more
TL;DR: To compare directly, in the same patient cohort, the ease of use and tolerability of donepezil and galantamine in the treatment of Alzheimer's disease (AD), and investigate the effects of both treatments on cognition and activities of daily living (ADL).