R
Rita Castro
Researcher at Pennsylvania State University
Publications - 71
Citations - 3284
Rita Castro is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Syphilis & Homocysteine. The author has an hindex of 24, co-authored 64 publications receiving 2721 citations. Previous affiliations of Rita Castro include University of Lisbon & Universidade Nova de Lisboa.
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Epigenetic Modifications Basic Mechanisms and Role in Cardiovascular Disease
TL;DR: The role of nutritional and environmental challenges in generational inheritance and epigenetic modifications, concentrating on examples that relate to complex cardiovascular diseases, is discussed, and the mechanisms by which homocysteine modifies epigenetic tags are dissected.
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Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease
Rita Castro,Isabel Rivera,Eduard A. Struys,Erwin E.W. Jansen,Paula Ravasco,Maria Ermelinda Camilo,Henk J. Blom,Cornelis Jakobs,Isabel Tavares de Almeida +8 more
TL;DR: Global DNA methylation may be altered in vascular disease, with a concomitant increase in plasma tHcy and AdoHcy.
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Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview.
TL;DR: Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for atherosclerosis and vascular disease and a link has been postulated between homocysteine, or its intermediates, and an alterated DNA methylation pattern.
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5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation
Rita Castro,Isabel Rivera,Paula Ravasco,Maria Ermelinda Camilo,Cornelis Jakobs,Henk J. Blom,I T de Almeida +6 more
TL;DR: A common 677C→T transition in the MTHFR gene is a well established genetic determinant of hyperhomocysteinaemia, and results in a thermolabile protein, with a decreased enzymatic activity.
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The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art
TL;DR: The biosynthesis and catabolism of Hcy is examined and recent findings linking disruption of this metabolism and endothelial dysfunction are critically revised, emphasizing the impact of HHcy on endothelial cell methylation status.