R
Rita Mukhopadhyay
Researcher at FIU Herbert Wertheim College of Medicine
Publications - 45
Citations - 4564
Rita Mukhopadhyay is an academic researcher from FIU Herbert Wertheim College of Medicine. The author has contributed to research in topics: Arsenite & Arsenate reductase. The author has an hindex of 28, co-authored 45 publications receiving 4222 citations. Previous affiliations of Rita Mukhopadhyay include Florida International University & Wayne State University.
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Microbial arsenic: from geocycles to genes and enzymes.
TL;DR: The DNA sequencing and protein crystal structures have established the convergent evolution of three classes of arsenate reductases, which involve three cysteine thiols and S-As bond intermediates, so convergence evolution to similar mechanisms has taken place.
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Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9
TL;DR: The results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenic as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia.
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Arsenate reductases in prokaryotes and eukaryotes.
Rita Mukhopadhyay,Barry P. Rosen +1 more
TL;DR: The yeast Acr2p has an active site motif HC(X)(5)R that is conserved in protein phosphotyrosine phosphatases and rhodanases, suggesting that these three groups of enzymes may have evolved from an ancestral oxyanion-binding protein.
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Drug Uptake and Modulation of Drug Resistance in Leishmania by an Aquaglyceroporin
Benjamin Gourbal,Niluefer Sonuc,Hiranmoy Bhattacharjee,Danielle Légaré,Shyam Sundar,Marc Ouellette,Barry P. Rosen,Rita Mukhopadhyay +7 more
TL;DR: This is the first report of the uptake of a metalloid drug by an aquaglyceroporin in Leishmania, suggesting a strategy to reverse resistance in the field.
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Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.
Rita Mukhopadhyay,Saibal Dey,Naxing Xu,Douglas A. Gage,James Lightbody,Marc Ouellette,Barry P. Rosen +6 more
TL;DR: It is demonstrated that promastigotes of arsenite-resistant Leishmania tarentolae have increased levels of intracellular thiols, and a model for drug resistance is proposed in which Sb(V)/As(V)-containing compounds are reduced intrACEllularly to Sb/As(III), conjugated to trypanothione, and extruded by the As-thiol pump.