Rivka Ishai-Michaeli

TL;DR: It is suggested that endothelium can store growth factors capable of autocrine growth promotion in two ways: by sequestering growth factor within the cell and by incorporating it into the underlying extracellular matrix.

TL;DR: This represents the first cloned mammalian heparanase, to the authors' knowledge, and provides direct evidence for its role in tumor metastasis, and enables the development of specific molecular probes for early detection and treatment of cancer metastasis and autoimmune disorders.

TL;DR: It is suggested that heparanase is utilized for this purpose by both normal leukocytic cells and metastatic tumor cells, and may elicit an indirect neovascular response in processes such as wound repair, inflammation and tumor development.

TL;DR: The angiogenic effect of heparanase was demonstrated in vivo by showing a three‐ to fourfold increase in neovascularization induced by murine T‐lymphoma cells after stable transfection with the heparinase gene.

TL;DR: Results and studies on the properties of other ECM‐immobilized enzymes and growth factors suggest that the ECM provides a storage depot for biologically active molecules which are thereby stabilized and protected and may allow a more localized and presistent mode of action, as compared to the same molecules in a fluid phase.