Showing papers by "Robert C. Moellering published in 1980"
TL;DR: The clinical features of 19 patients with prosthetic valve endocarditis due to diphtheroids and biochemical and physiologic features of 20 strains were studied; with the exception of colonial morphology, 18 strains were found to be similar.
100 citations
TL;DR: In an eight year period 16 cases of serious extrapulmonary Hemophilus influenzae infection in adults were identified, including cases of meningitis, pericarditis, epiglottitis, empyema, cellulitis, osteomyelitis, endometritis, urinary tract infection, orbital cellulitis and primary peritonitis.
70 citations
TL;DR: A patient with enterococcal endocarditis, who relapsed after repeated courses of apparently adequate treatment with ampicillin plus gentamicin, was subsequently cured withAmpicillin-tobramycin therapy, and the organisms isolated from this patient were strains of Streptococcus faecalis that were resistant to penicillin-gentamicin synergism.
Abstract: A patient with enterococcal endocarditis, who relapsed after repeated courses of apparently adequate treatment with ampicillin plus gentamicin, was subsequently cured with ampicillin-tobramycin therapy. The organisms isolated from this patient were strains of Streptococcus faecalis that were resistant to penicillin (or ampicillin)-gentamicin synergism but not to penicillin (or ampicillin)-tobramycin synergism. The mechanism of resistance in these strains appears to be related to a specific defect in the intracellular uptake of gentamicin (but not tobramycin) in the presence of penicillin.
41 citations
TL;DR: Two blood culture isolates of Acinetobacter calcoaceticus subsp.
Abstract: Two blood culture isolates of Acinetobacter calcoaceticus subsp anitratus (Herellea vaginicola) were recently observed to be unusually resistant to aminoglycosides Each strain was found to contain aminoglycoside-modifying enzymes which have not been described previously in this species, including 2"-adenylyltransferase, 3"-adenylyltransferase, 3'-phosphotransferase-III, and 3-acetyltransferase Treatment of one strain (H-S) with novobiocin led to a loss of resistance to multiple antimicrobial agents and a loss of two aminoglycoside-modifying enzymes; agarose gel electrophoresis of lysates of this strain revealed that the loss of resistance markers was associated with the loss of a large-molecular-weight plasmid Treatment of the second strain (H-D) with novobiocin produced derivative strains with three different resistance patterns Agarose gel electrophoresis of deoxyribonucleic acid from crude lysates and from cesium chloride-ethidium bromide gradients of this strain showed only a small plasmid (molecular weight, 5 X 10(6)) common to all variants and failed to explain the loss of resistance markers
40 citations
TL;DR: The major adverse reactions to antibiotics are reviewed so that side effects may be promptly recognized and treated and the surgeon can more effectively utilize this valuable class of drugs for the benefit of the patient.
17 citations
3 citations