Robert C. Moellering

TL;DR: Three types of antimicrobial combination or interaction result in enhanced (synergistic) antimicrobial activity: combinations of agents that inhibit bacterial cell wall synthesis with aminoglycosidic aminocyclitols, the use of beta-lactamase inhibitors in combination with beta- lactam antibiotics, and the administration ofagents that act on sequential steps in one of the bacterial metabolic or synthetic pathways.

TL;DR: Two new quinolones were bactericidal against gram-negative bacilli during the first 6 h of incubation, but against S. aureus and enterococci the drugs were primarily bacteriostatic during this period, and resistance to concentrations of the drug greater than 100 micrograms/ml remained stable after passage on antibiotic-free media in only 1 of 35 strains tested.

TL;DR: The Clinical Consensus Conference on Gram-Positive Bloodstream Infections was convened as a session at the 9th International Symposium on Modern Concepts in Endocarditis and Cardiovascular Infections, and participants discussed various aspects of the practical treatment of patients who present with gram-positive BSI.

TL;DR: Two glycopeptide antibiotics, vancomycin and teicoplanin, are currently available for clinical use in various parts of the world, whereas a third, avoparcin, is available for use in agricultural applications and in veterinary medicine in some countries.

TL;DR: Several antimicrobial regimens were evaluated in the treatment of experimental enterococcal endocarditis due to a beta-lactamase-producing, highly gentamicin-resistant strain of Enterococcus faecalis, and valves remained sterile in four of five rats treated with ampicillin-sulbactam, in five of seven treated with daptomycin, but in only one of eight receiving vancomycin.