https://macsphere.mcmaster.ca/bitstream/11375/21808/1/Duncan%20et%20al%2c%202009%2c%20Clinical%20Neurophysiology.pdf

Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400.

Sharon Abel, PhD Jane Baran, PhD Anthony Cacace, PhD Gail Chermak, PhD$ Susan Dalebout, PhD Jay Hall 111, PhD Linda Hood, PhD Lisa Hunter, PhD James Jerger, PhD Susan Jerger, PhD Robert Keith, PhD Frank Musiek, PhD Ross Roeser, PhD Christine Sloan, PhD University of Toronto, Toronto, ON University of Massachusetts, Amherst, MA Albany Medical College, Albany, NY Washington State University, Pullman, WA University of Virginia, Charlottesville,VA University of Florida, Gainesville, FL Louisiana State University Medical Center, New Orleans, LA University of Minnesota, Minneapolis, MN University of Texas at Dallas, Dallas, TX University of Texas at Dallas, Dallas, TX University of Cincinnati, Cincinnati, OH Dartmouth-Hitchcock Medical Center, Hanover, NH University of Texas at Dallas, Dallas, TX Annapolis Valley Regional School Board Berwick, NS

Report of the Consensus Conference on the Diagnosis of Auditory Processing Disorders in School-Aged Children.

Central Auditory Processing: Current Status of Research and Implications for Clinical Practice Task Force on Central Auditory Processing Consensus Development

Neural plasticity following auditory training in children with learning problems.

Motivated by auditory and speech deficits in autism spectrum disorders (ASD), the frequency dependence of superior temporal gyrus (STG) 50 msec (M50) and 100 msec (M100) neuromagnetic auditory evoked field responses in children with ASD and typically developing controls were evaluated. Whole-cortex magnetoencephalography (MEG) was obtained from 17 typically developing children and 25 children with ASD. Subjects were presented tones with frequencies of 200, 300, 500, and 1,000 Hz, and left and right STG M50 and M100 STG activity was examined. No M50 latency or amplitude Group differences were observed. In the right hemisphere, a Group × Frequency ANOVA on M100 latency produced a main effect for Group (P 5 0.01), with an average M100 latency delay of 11 msec in children with ASD. In addition, only in the control group was the expected association of earlier M100 latencies in older than younger children observed. Group latency differences remained significant when hierarchical regression analyses partialed out M100 variance associated with age, IQ, and language ability (all P-values < 0.05). Examining the right-hemisphere 500 Hz condition (where the largest latency differences were observed), a sensitivity of 75%, a specificity of 81%, and a positive predictive value (PPV) of 86% was obtained at a threshold of 116 msec. The M100 latency delay indicates disruption of encoding simple sensory information. Given similar findings in language impaired and nonlanguage impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism.

/pdf/meg-detection-of-delayed-auditory-evoked-responses-in-autism-2c3ggt3kk8.pdf

MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism.

The purpose of this study was to evaluate auditory event-related potentials, and related long latency components, in children with auditory processing disorders, and to compare these results with a normal group matched for age, intelligence, and gender. Results showed a significant latency increase for the N1, P2, and P3 components in the processing disordered group. Furthermore, the interpeak latency interval P2-P3 was significantly longer in the clinical group. In terms of amplitude measures, only P3 amplitude differed significantly between groups. These results suggest that the long latency potentials may be useful in the assessment of children with processing disorders.

Long Latency Auditory Event-Related Potentials from Children with Auditory Processing Disorders

This study investigated whether the P3 AERP could be used to reflect behavioral changes resulting from therapeutic intervention in a group of children with central auditory processing disorders (CAPDs). Results showed a significant decrease in P3 latency, along with a significant increase in P3 amplitude, following a structured treatment program. No changes occurred in either the CAPD control group or in the normal control group. These results suggest that the P3 AERP latency and amplitude measures are sensitive to changes in clinical status following a treatment program.

Robert E. Jirsa

Papers

Long Latency Auditory Event-Related Potentials from Children with Auditory Processing Disorders

The Clinical Utility of the P3 AERP in Children With Auditory Processing Disorders