R
Robert F. Gonzalez
Researcher at University of California, San Francisco
Publications - 23
Citations - 2146
Robert F. Gonzalez is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung & Alveolar Epithelium. The author has an hindex of 16, co-authored 23 publications receiving 2053 citations.
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Journal ArticleDOI
An improved method for isolating type II cells in high yield and purity.
TL;DR: Type II cells isolated by "panning" adhered more rapidly and completely in tissue culture than did cells isolate by centrifugation over discontinuous density gradients of metrizamide.
Journal ArticleDOI
Monoclonal antibodies specific to apical surfaces of rat alveolar type I cells bind to surfaces of cultured, but not freshly isolated, type II cells.
TL;DR: Type II cells maintained in culture acquire immunoreactivity to monoclonal antibodies, demonstrating that type II cells in vitro have the capacity to develop a characteristic associated with type I cells in situ.
Journal ArticleDOI
Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells
Leland G. Dobbs,Jo Rae Wright,Samuel Hawgood,Robert F. Gonzalez,Kristy Venstrom,Jean Nellenbogen +5 more
TL;DR: Findings that suggest that surfactant inhibits secretion of 3H-labeled phosphatidylcholine by cultured rat type II cells are compatible with the hypothesis that Surfactant secretion is under feedback regulatory control.
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Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung
Leland G. Dobbs,Robert F. Gonzalez,Michael A. Matthay,Ethan P. Carter,Lennell Allen,Alan S. Verkman +5 more
TL;DR: The purpose of this study was to test whether osmotic water permeability in type I alveolar epithelial cells is high enough to account for the high Pf of the intact lung.
Journal ArticleDOI
CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury.
Jeff N. Vanderbilt,Edward M. Mager,Lennell Allen,Teiji Sawa,Jeanine P. Wiener-Kronish,Robert F. Gonzalez,Leland G. Dobbs +6 more
TL;DR: It is shown that freshly isolated alveolar Type II (TII) cells express three of the major proinflammatory CXC chemokines (GRO, CINC-2alpha, and MIP-2) and their cognate receptor CXCR2 and this support a central role for the TII cell as an immunologic effector cell in the alveolus.