R
Robert Fraser
Researcher at Western Infirmary
Publications - 207
Citations - 7790
Robert Fraser is an academic researcher from Western Infirmary. The author has contributed to research in topics: Aldosterone & Angiotensin II. The author has an hindex of 48, co-authored 207 publications receiving 7684 citations. Previous affiliations of Robert Fraser include British Heart Foundation.
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Journal ArticleDOI
Cortisol Effects on Body Mass, Blood Pressure, and Cholesterol in the General Population
Robert Fraser,Mary C. Ingram,Niall H. Anderson,Caroline Morrison,Eleanor Davies,John M. C. Connell +5 more
TL;DR: The results suggest that glucocorticoids regulate key components of cardiovascular risk in normal individuals and that cortisol excretion rate with HDL cholesterol in men and women and with body mass index in men.
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Abnormalities of glucocorticoid metabolism and the renin—angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure
Graham Watt,Stephen B. Harrap,C. J. W. Foy,D. W. Holton,H. V. Edwards,H. R. Davidson,J. M. Connor,Anthony F. Lever,Robert Fraser +8 more
TL;DR: The combined biochemical and genetic findings suggest that abnormalities of glucocorticoid metabolism and the renin-angiotensin system may help to explain genetic predisposition to high blood pressure.
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Aldosterone Excretion Rate and Blood Pressure in Essential Hypertension Are Related to Polymorphic Differences in the Aldosterone Synthase Gene CYP11B2
Eleanor Davies,Christine D. Holloway,Mary C. Ingram,G. C. Inglis,E Friel,Caroline Morrison,Niall H. Anderson,Robert Fraser,John M. C. Connell +8 more
TL;DR: Urinary aldosterone excretion rate may be a useful intermediate phenotype linking these genotypes to raised BP, and it is possible that the polymorphisms may be in linkage with other causative mutations.
Journal ArticleDOI
The angiotensin I converting enzyme gene and predisposition to high blood pressure.
Stephen B. Harrap,H. R. Davidson,J. M. Connor,F. Soubrier,P. Corvol,Robert Fraser,C. J. W. Foy,G. C. M. Watt +7 more
TL;DR: The results suggest that in a group of Caucasians selected from the general population, the ACE gene is not associated with genetic predisposition to high blood pressure, and common ACE gene allelic markers would not be useful indexes of susceptibility to hypertension.
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Sensitization of the Adrenal Cortex to Angiotensin II in Sodium-Deplete Man
TL;DR: The contrasting effects of sodium depletion on the aldosterone and the pressor dose-response curves favored sodium retention, consistent with an important role for the renin-angiotensin system in the control of ald testosterone secretion in man.