R
Robert H. Pollack
Researcher at Columbia University
Publications - 189
Citations - 6458
Robert H. Pollack is an academic researcher from Columbia University. The author has contributed to research in topics: Cell culture & Illusion. The author has an hindex of 41, co-authored 185 publications receiving 6382 citations. Previous affiliations of Robert H. Pollack include Cold Spring Harbor Laboratory & New York University.
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Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.
TL;DR: Results suggest that the single cellular property consistently associated with tumorigenicity in nude mice is the acquisition by virus-transformed cells of the ability to proliferate in vitro in the absence of anchorage.
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Patterns of organization of actin and myosin in normal and transformed cultured cells
TL;DR: A consistent correlation was found between sensitivity to anchorage-dependent growth control and the presence of large, thick sheaths of actin-containing material in a rat line transformed by a temperature-sensitive mutant in the complementation group A of the oncogenic virus simian virus 40.
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Growth control in cultured cells: selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability.
TL;DR: As growing cultures of mammalian cells reach a high density, their growth rate decreases and in some cases a substantially nondividing population may result, this arrest of growth requires cell contact, though soluble substances are also involved.
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A nonselective analysis of SV40 transformation of mouse 3T3 cells.
Rex Risser,Robert H. Pollack +1 more
TL;DR: Analysis of the growth properties of 40 randomly selected colonies arising after SV40 infection of 3T3 cells revealed that only 5 of the clones were indistinguishable from 3T2 cells; the remaining 35 clones differed from 3 T3 cells in that they grew as rapidly in 1% calf serum as standard SV40 transformed cells.
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The distribution of actin in non-muscle cells. The use of actin antibody in the localization of actin within the microfilament bundles of mouse 3T3 cells.
TL;DR: Electron microscopy reveals that living mouse 3T3 cells display a complex array of fibrous structures which are visible with phase contrast, Nomarski and polarized light optics and consist of submembranous bundles of microfilaments located primarily on the attached side of the cells.