R
Robert Johnston
Publications - 6
Citations - 922
Robert Johnston is an academic researcher. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 3, co-authored 3 publications receiving 540 citations.
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Journal ArticleDOI
Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TL;DR: In this paper, the authors provide a clinicopathological report of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases by documenting histopathological changes and evidence of SARS CoV2 tissue tropism.
Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Gail H. Deutsch,J Matthew Lacy,Timothy L. Williams,Nicole A. Yarid,Desiree A. Marshall +11 more
TL;DR: A clinicopathological report of severe COVID-19 cases by documenting histopathological changes and evidence of SARS-CoV-2 tissue tropism is provided.
Posted ContentDOI
Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections
Benjamin T. Bradley,Heather Maioli,Robert Johnston,Irfan Chaudhry,Susan L. Fink,Haodong Xu,Behzad Najafian,Desiree A. Marshall,Lacy Jm,Timothy J. Williams,Nicole A. Yarid +10 more
TL;DR: SARS-CoV-2 represents the third novel coronavirus to cause widespread human disease since 2002, and the primary pathology was diffuse alveolar damage with virus located in the pneumocytes, however, other major organs including the heart and kidneys may be susceptible to viral replication and damage leading to increased mortality in those with disseminated disease.
Proceedings ArticleDOI
475 Anti-TIGIT antibody tiragolumab leverages myeloid cells and regulatory T cells to improve PD-L1 checkpoint blockade
Namrata Patil,Raymond Meng,Robert Johnston,Patrick Chang,Shyam Srivats,Yoonha Choi,Xiangnan Guan,Barzin Y. Nabet,Lisa McGinnis,Eugene Chiang,Thinh Pham,Alexis Dunkle,B. O'Gorman,Ira Mellman,Ruozhen Hu,Johnny Silva,Joy Han,Amelia Au-Yeung,Chikara Takahashi,Nandini Molden,Pallavi Daggumati,Wendy Connolly,Melissa Johnson,Delvys Rodriguez Abreu,Byoung Chul Cho,Antoine Italiano,Ignacio Gil Bazo,Enriqueta Felip,Sanjeev Mariathasan,Carlos Bais,David S. Shames +30 more
TL;DR: Tiragolumab + atezolizumab (anti-PD-L1) combination treatment demonstrated significant improvement relative to TIGIT alone in non-small cell lung cancer (NSCLC) as mentioned in this paper .
Journal ArticleDOI
P613: tlr9 signalling is a potential tumour escape mechanism following btki therapy for the treatment of chronic lymphocytic leukaemia.
Eileen Margaret Kennedy,S. Mitchell,Thomas A Burley,Triantafillos Liloglou,Robert Johnston,I. Ashworth,D. Bak-Blaz,Kristen Chamberlain,Eleni E Ladikou,S. Mackay,Chris Pepper,Andrea Pepper +11 more
TL;DR: In this paper , the authors investigated TLR9 activation as a potential mechanism of resistance to current B-cell receptor (BCR)-targeted therapeutics and found that TLR 9 activation induced a dichotomous migratory response in CLL patient samples.