Showing papers by "Robert L. Reid published in 1981"
TL;DR: In both male and female subjects this dose of β-endorphin induced a significant increase in the levels of PRL and a significant decline in the concentration of LH, without altering basal levels of GH and TSH.
Abstract: The disappearance rate of the immunoreactive βh-endorphin and the effects of βh-endorphin on pituitary hormone secretion were investigated in normal volunteers. Synthetic human βh-endorphin was administered as a 2.5-mg iv bolusto five normal women resulting in a 1000-fold increase in concentration of circulating immunoreactive βh-endorphin within 2.5 min. This was followed by a triple exponential disappearance curve yielding an initial fast component with a halftime (t½ ± SD)of 4.1 (± 0.6) min, a midrange component with a t½ of 13.1 (± 0.6) min,and a slow component with (t½ of 46.2 (± 7.0) min. In both male and female subjects this dose of β-endorphin induced a significant increase in the levels of PRL and a significant decline in the concentration of LH, without altering basal levels of GH and TSH.
156 citations
TL;DR: A possible role for beta-endorphin in the regulation of alpha and beta cell function within the pancreatic islets is suggested.
Abstract: Administration of β-endorphin as an iv bolus elicited an acute and simultaneous rise in insulin and glucagon levels within 5 min in fasting normal male and female subjects. This was followed by an increase in the concentration of plasma glucose. The elevation of plasma insulin, glucagon and glucose levels lasted for up to 120 min. These observations suggest a possible role for β-endorphin in the regulation of α and β cell function within the pancreatic islets.
143 citations
TL;DR: The efficacy of intravenous and subcutaneous routes for pulsatile delivery of differing dosages of synthetic luteinizing hormone releasing factor for ovulation induction were evaluated sequentially in two patients with presumed deficiency of endogenous LRF: isolated gonadotropin deficiency and pituitary stalk transection with hyperprolactinemia.
104 citations
TL;DR: It is demonstrated that synthetic α-MSH given as a 2.5 nig intravenous bolus induces an unequivocal rise in LH and PSH in male subjects but not in femalesubjects during the low estrogen phase of the cycle.
Abstract: The present study demonstrates that synthetic α-MSH given as a 2.5 nig intravenous bolus induces an unequivocal rise in LH and PSH in male subjects but not in femalesubjects during the low estrogen phase of the cycle.
23 citations
11 citations