A. Primary Alcohols as Nucleophiles 2931 B. Carboxylates as Nucleophiles 2931 C. Alkylations with Phenols 2932 IV. Nitrogen Nucleophiles in AAA Total Synthesis 2935 A. Alkylamines as Nucleophiles 2935 B. Azides as a Nucleophile 2936 C. Sulfonamide Nucleophiles 2937 D. Imide Nucleophiles 2938 E. Heterocyclic Amine Nucleophiles 2940 V. Sulfur Nucleophiles 2941 VI. Summary and Conclusions 2941 VII. Acknowledgment 2941 VIII. References 2942 I. Considerations for Enantioselective Allylic Alkylation

http://athena.uwindsor.ca/users/j/jlichaa/reference.nsf/54ef3e94e5fe816e85256d6e0063d208/10ff8b04ff3a317885256d88005720f6/$file/cr-2003-103-2921-trost-allylpd.pdf

Asymmetric transition-metal-catalyzed allylic alkylations: applications in total synthesis.

Spectra of porphyrins

An important first step in making organic reactions more environmentally benign by design requires processes that are, to a first approximation, simple additions with anything else needed only catalytically. Since so few of the existing reactions are additions, synthesis of complex molecules requires the development of new atom-economic methodology. The prospect for such developments is probed in the context of ruthenium-catalyzed reactions. Using mechanistic reasoning, over 20 new processes of varying complexity have been designed and implemented. While some involved oxidation−reduction processes, most involved C−C bond-forming reactions.

On Inventing Reactions for Atom Economy

Chlorophyll a Determination: Improvements in Methodology

Ruthenium-Catalyzed Reactions for Organic Synthesis.

Two-metal catalyst system for redox isomerization of propargyl alcohols to enals and enones.

Catalytic ruthenium complexes in conjunction with an indium cocatalyst and Bronsted acid isomerize primary and secondary propargylic alcohols in good yields to provide trans enals and enones exclusively. Readily available indenylbis(triphenylphosphine)ruthenium chloride, in the presence of indium triflate and camphorsulfonic acid, gives the best turnover numbers and reactivity with the broadest range of substrates. Deuterium labeling experiments suggest that the process occurs through propargylic hydride migration followed by protic cleavage of the resultant vinylruthenium intermediate. Application of this method to the synthesis of leukotriene B4 demonstrates its utility and extraordinary selectivity.

An Atom-Economic and Selective Ruthenium-Catalyzed Redox Isomerization of Propargylic Alcohols. An Efficient Strategy for the Synthesis of Leukotrienes

Activation of the Fluorescence of Chlorophyll Solutions

The Ruthenium catalyzed, atom-economical domino redox isomerization/cyclization of tethered aminopropargyl alcohols is reported This process displays a broad scope and functional group tolerance 

/pdf/a-ruthenium-catalyzed-atom-economical-synthesis-of-nitrogen-4miwyoqy0o.pdf

Robert Livingston

Papers

Two-metal catalyst system for redox isomerization of propargyl alcohols to enals and enones.

An Atom-Economic and Selective Ruthenium-Catalyzed Redox Isomerization of Propargylic Alcohols. An Efficient Strategy for the Synthesis of Leukotrienes

Activation of the Fluorescence of Chlorophyll Solutions

A Ruthenium-Catalyzed, Atom-Economical Synthesis of Nitrogen Heterocycles

Quenching of the Fluorescence of Chlorophyll a Solutions1