Robert M. Owen

TL;DR: In this paper, the authors show that bottom water temperature increased by more than 4°C during a brief time interval (<104 years) of the latest Paleocene (∼55.6 Ma) and there also was a coeval −2 to −3‰ excursion in the δ13C of the ocean/atmosphere inorganic carbon reservoir.

TL;DR: The compilation and analysis of combined data on the attrition of drug candidates from AstraZeneca, Eli Lilly and Company, GlaxoSmithKline and Pfizer reaffirms that control of physicochemical properties during compound optimization is beneficial in identifying compounds of candidate drug quality and indicates for the first time a link between the physic biochemical properties of compounds and clinical failure due to safety issues.

TL;DR: The goal was to devise a strategy to mediate selective killing of tumor cells, which are often distinguished from normal cells by their higher levels of particular cell surface receptors, and to test whether multivalent interactions could lead to highly specific cell targeting.

TL;DR: This Perspective seeks to review the ion channel family, its structural and functional features, and the diseases that are known to be modulated by members of the family and explores the structure and properties of known ligands.

TL;DR: In this paper, the authors show that the REE composition of the hydrothermal component is primarily acquired via scavenging from seawater, and conclude that the residual energy of the sediment is derived from the interaction of seawater and Fe in the plume.