L
Laura L. Kiessling
Researcher at Massachusetts Institute of Technology
Publications - 324
Citations - 17769
Laura L. Kiessling is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Racism & Glycan. The author has an hindex of 68, co-authored 311 publications receiving 16433 citations. Previous affiliations of Laura L. Kiessling include California Institute of Technology & Wisconsin Alumni Research Foundation.
Papers
More filters
Journal Article
Chemical glycobiology : Carbohydrates and glycobiology
TL;DR: Chemical tools have proven indispensable for studies in glycobiology and chemical approaches are contributing great insight into the myriad biological functions of oligosaccharides.
Journal ArticleDOI
Synthetic Multivalent Ligands as Probes of Signal Transduction
TL;DR: This Review focuses on the use of synthetic multivalent ligands to characterize receptor function through chemical synthesis to address the role of receptor assembly in signal transduction.
Journal ArticleDOI
Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture
Jason E. Gestwicki,Christopher W. Cairo,Laura E. Strong,Karolyn A. Oetjen,Laura L. Kiessling +4 more
TL;DR: It is found that ligands with certain architectures are effective inhibitors, but others mediate receptor clustering, whereas linear oligomeric ligands generated by the ring-opening metathesis polymerization have structural properties that favor clustering.
Journal ArticleDOI
How many human proteoforms are there
Ruedi Aebersold,Jeffrey N. Agar,I. Jonathan Amster,Mark S. Baker,Carolyn R. Bertozzi,Emily S. Boja,Catherine E. Costello,Benjamin F. Cravatt,Catherine Fenselau,Benjamin A. Garcia,Ying Ge,Jeremy Gunawardena,Ronald C. Hendrickson,Paul J. Hergenrother,Christian G. Huber,Alexander R. Ivanov,Ole N. Jensen,Michael C. Jewett,Neil L. Kelleher,Laura L. Kiessling,Nevan J. Krogan,Martin R. Larsen,Joseph A. Loo,Rachel R. Ogorzalek Loo,Emma Lundberg,Emma Lundberg,Michael J. MacCoss,Parag Mallick,Vamsi K. Mootha,Milan Mrksich,Tom W. Muir,Steven M. Patrie,James J. Pesavento,Sharon J. Pitteri,Henry Rodriguez,Alan Saghatelian,Wendy Sandoval,Hartmut Schlüter,Salvatore Sechi,Sarah A. Slavoff,Lloyd M. Smith,Michael Snyder,Paul M. Thomas,Mathias Uhlén,Jennifer E. Van Eyk,Marc Vidal,David R. Walt,Forest M. White,Evan R. Williams,Therese Wohlschlager,Vicki H. Wysocki,Nathan A. Yates,Nicolas L. Young,Bing Zhang +53 more
TL;DR: This work frames central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today, and uses this framework to assess existing data and ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?"
Journal ArticleDOI
Synthetic multivalent ligands in the exploration of cell-surface interactions.
TL;DR: Synthetic multivalent ligands provide insight into how cells exploit multivalent interactions to bind with increased avidity and specificity and how cell-surface receptor organization influences signaling and the cellular responses that result.