R
Robert Mabry
Researcher at ZymoGenetics
Publications - 23
Citations - 1129
Robert Mabry is an academic researcher from ZymoGenetics. The author has contributed to research in topics: Antibody & Monoclonal antibody. The author has an hindex of 12, co-authored 21 publications receiving 1081 citations. Previous affiliations of Robert Mabry include Dartmouth College & University of Texas at Austin.
Papers
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Journal ArticleDOI
Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli.
TL;DR: In this article, the authors describe facile isolation of full-length IgG antibodies from combinatorial libraries expressed in E. coli, where heavy and light chains are secreted into the periplasm, where they assemble into aglycosylated IgGs that are captured by an Fc-binding protein that is tethered to the inner membrane.
Journal ArticleDOI
Isolation and expression of recombinant antibody fragments to the biological warfare pathogen Brucella melitensis.
Andrew Hayhurst,Scott Happe,Scott Happe,Robert Mabry,Zephyr Koch,Brent L. Iverson,George Georgiou +6 more
TL;DR: The isolated phage antibodies were shown to be highly specific to B. melitensis and did not recognize Yersinia pseudotuberculosis in contrast to the existing diagnostic monoclonal YST 9.2.1.
Journal ArticleDOI
Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody.
Harald Rouha,Adriana Badarau,Zehra Visram,Michael B. Battles,Bianka Prinz,Zoltán Magyarics,Gábor Nagy,Irina Mirkina,Lukas Stulik,Manuel Zerbs,Michaela Jägerhofer,Barbara Maierhofer,Astrid Teubenbacher,Ivana Dolezilkova,Karin Gross,Srijib Banerjee,Gerhild Zauner,Stefan Malafa,Jakub Zmajkovic,Sabine Maier,Robert Mabry,Eric Krauland,K. Dane Wittrup,Tillman U. Gerngross,Eszter Nagy +24 more
TL;DR: It is found that a single cross-reactive antibody prevented lysis of human phagocytes, epithelial and red blood cells induced by α-hemolysin and leukocidins in vitro, and therefore had superior effectiveness compared to α- hemolysin specific antibodies to protect from the combined cytolytic effect of secreted S. aureus toxins.
Journal ArticleDOI
Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays
Robert Mabry,Kathleen M. Brasky,Robert Geiger,Ricardo Carrion,Gene B. Hubbard,Stephen H. Leppla,Jean L. Patterson,George Georgiou,Brent L. Iverson +8 more
TL;DR: Simple anthrax toxin detection ELISAs could prove useful in the evaluation of potential therapies and possibly as a clinical diagnostic to complement other strategies for the rapid identification of B. anthracis infection.
Patent
Il-17 and il-23 antagonists and methods of using the same
TL;DR: In this paper, the authors proposed a method for blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit.