R
Robert S. Britton
Researcher at Saint Louis University
Publications - 90
Citations - 7505
Robert S. Britton is an academic researcher from Saint Louis University. The author has contributed to research in topics: Hereditary hemochromatosis & Hemochromatosis. The author has an hindex of 43, co-authored 90 publications receiving 7322 citations. Previous affiliations of Robert S. Britton include Fremantle Hospital & Case Western Reserve University.
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Journal ArticleDOI
HFE gene knockout produces mouse model of hereditary hemochromatosis
Xiao Yan Zhou,Shunji Tomatsu,Robert E. Fleming,Seppo Parkkila,Abdul Waheed,Jinxing Jiang,Ying Fei,Elizabeth M. Brunt,David A. Ruddy,Cynthia E. Prass,Randall C. Schatzman,Rosemary O'Neill,Robert S. Britton,Bruce R. Bacon,William S. Sly +14 more
TL;DR: The knockout mouse model of HH will facilitate investigation into the pathogenesis of increased iron accumulation in HH and provide opportunities to evaluate therapeutic strategies for prevention or correction of iron overload.
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Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells
Abdul Waheed,Seppo Parkkila,Xiao Yan Zhou,Shunji Tomatsu,Zenta Tsuchihashi,John N. Feder,Randall C. Schatzman,Robert S. Britton,Bruce R. Bacon,William S. Sly +9 more
TL;DR: In this article, the effects of the Cys-282→Tyr (C282Y) mutation on the cellular trafficking and degradation of the HFE protein in transfected COS-7 cells were investigated.
Journal ArticleDOI
The pathology of hepatic iron overload: a free radical--mediated process?
Bruce R. Bacon,Robert S. Britton +1 more
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Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
Seppo Parkkila,Abdul Waheed,Robert S. Britton,Bruce R. Bacon,Xiao Yan Zhou,Shunji Tomatsu,Robert E. Fleming,William S. Sly +7 more
TL;DR: It is demonstrated by immunohistochemistry that the HFE protein is expressed in human placenta in the apical plasma membrane of the syncytiotrophoblasts, where the transferrin-bound iron is normally transported to the fetus via receptor-mediated endocytosis.
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Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
Robert E. Fleming,Mary C. Migas,Christopher C. Holden,Abdul Waheed,Robert S. Britton,Shunji Tomatsu,Bruce R. Bacon,William S. Sly +7 more
TL;DR: It is proposed that TfR2 allows continued uptake of Tf-bound iron by hepatocytes even after Tf R has been down-regulated by iron overload, and this uptake contributes to the susceptibility of liver to iron loading in HH.