R
Robert T. Sauer
Researcher at Massachusetts Institute of Technology
Publications - 408
Citations - 42127
Robert T. Sauer is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Repressor & Protein degradation. The author has an hindex of 106, co-authored 402 publications receiving 40181 citations. Previous affiliations of Robert T. Sauer include University of California, San Francisco & Harvard University.
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Journal ArticleDOI
Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease.
P. R. H. Waller,Robert T. Sauer +1 more
TL;DR: The result and the inability of a plasmid expressing degS to rescue the temperature-sensitive degP41 phenotype indicate that the DegS protein is functionally different from the DegQ and DegP proteins.
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Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress
TL;DR: In this article, the authors found that off-pathway intermediates in lipopolysaccharide transport and assembly provided an additional required signal for the degradation of a negative regulator of the σ(E) transcription factor.
Journal ArticleDOI
Reverse hydrophobic effects relieved by amino-acid substitutions at a protein surface
Andrew Pakula,Robert T. Sauer +1 more
TL;DR: It is shown that the stability of Cro can be increased by many different amino-acid substitutions at position 26, with increasing stability showing a good correlation with decreasing side-chain hydrophobicity.
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Proline Residues at the C Terminus of Nascent Chains Induce SsrA Tagging during Translation Termination
TL;DR: The results suggest that the detailed chemical or conformational properties of the C-terminal residues of the nascent polypeptide can affect the rate of translation termination, thereby influencing ribosome pausing and SsrA tagging at stop codons.
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Communication between ClpX and ClpP during substrate processing and degradation
TL;DR: It is shown that ClpX-ClpP affinity varies with the protein-processing task of Clp X and with the catalytic engagement of the active sites of ClPP.