R
Robin E. Gandley
Researcher at University of Pittsburgh
Publications - 51
Citations - 1689
Robin E. Gandley is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Preeclampsia & Pregnancy. The author has an hindex of 21, co-authored 46 publications receiving 1547 citations. Previous affiliations of Robin E. Gandley include University of Maryland, College Park.
Papers
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Journal ArticleDOI
Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein.
Linda L. Pearce,Robin E. Gandley,Weiping Han,Karla J. Wasserloos,Molly S. Stitt,Anthony Kanai,Margaret K. McLaughlin,Bruce R. Pitt,Edwin S. Levitan +8 more
TL;DR: The utility of FRET-MT is demonstrated as an intracellular surrogate indicator of NO production and an important role of metal thiolate clusters of MT in NO signaling in vascular tissue is revealed.
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Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia.
TL;DR: The predominance of smaller, denser LDL, a potential contributor to endothelial cell dysfunction, is a feature of preeclampsia, but the serum VCAM-1 level may be influenced more by quantitative lipoprotein changes (serum apo B or LDL-cholesterol) than by LDL particle size.
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Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats.
TL;DR: Administration of the ovarian hormone relaxin to nonpregnant rats mimics pregnancy, insofar as myogenic reactivity of small renal and mesenteric arteries is reduced in both conditions.
Journal ArticleDOI
Binding of fatty acids facilitates oxidation of cysteine-34 and converts copper-albumin complexes from antioxidants to prooxidants.
Y.A. Gryzunov,Antonio Arroyo,Jean-Louis Vigne,Qing Zhao,Vladimir A. Tyurin,Carl A. Hubel,Robin E. Gandley,Yury A. Vladimirov,Robert N. Taylor,Valerian E. Kagan +9 more
TL;DR: It is concluded that fatty acids regulate anti-/prooxidant properties of Cu-albumin via controlling redox status of Cys-34, which is a transition metal capable of undergoing one-electron oxidation-reduction conversions.
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Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats.
TL;DR: It is concluded that endothelin mediates the NO-dependent changes in the renal circulation of conscious rats during pregnancy, strengthening the link between the renal endothelial ETBreceptor subtype and NO.