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Roby J. Jose
Researcher at James Cook University
Publications - 17
Citations - 497
Roby J. Jose is an academic researcher from James Cook University. The author has contributed to research in topics: Angiotensin II & Aortic aneurysm. The author has an hindex of 12, co-authored 17 publications receiving 407 citations. Previous affiliations of Roby J. Jose include Federation University Australia & L V Prasad Eye Institute.
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Journal ArticleDOI
Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis.
Smriti M. Krishna,Sai Wang Seto,Roby J. Jose,Jiaze Li,Susan K. Morton,Erik Biros,Yutang Wang,Vianne Nsengiyumva,Jan H.N. Lindeman,Gabriela G. Loots,Catherine M. Rush,Jeffrey M. Craig,Jonathan Golledge +12 more
TL;DR: It is identified that SOST is expressed in the aorta and downregulated in human AA possibly because of epigenetic silencing, and upregulating SOST inhibits AA and atherosclerosis development, with potential important implications for treating these vascular diseases.
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A Peptide Antagonist of Thrombospondin-1 Promotes Abdominal Aortic Aneurysm Progression in the Angiotensin II–Infused Apolipoprotein-E–Deficient Mouse
Smriti M. Krishna,Sai Wang Seto,Roby J. Jose,Erik Biros,Corey S. Moran,Yutang Wang,Paula Clancy,Jonathan Golledge +7 more
TL;DR: Attenuation of thrombospondin-1-directed activation of TGF-&bgr;1 promotes abdominal aortic aneurysm and atherosclerosis progression in the angiotensin II–infused ApoE−/− mouse model.
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Everolimus Limits Aortic Aneurysm in the Apolipoprotein E–Deficient Mouse by Downregulating C-C Chemokine Receptor 2 Positive Monocytes
Corey S. Moran,Roby J. Jose,Joseph V. Moxon,Alicia Roomberg,Paul Norman,Catherine M. Rush,Heinrich Körner,Jonathan Golledge +7 more
TL;DR: Systemic administration of everolimus limits aortic aneurysm in the A2-infused apolipoprotein E–deficient mouse model via suppressed development of bone marrow CCR2 monocytes and reduced egress of these cells into the circulation.
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Diagnosis of herpes simplex virus-1 keratitis: Comparison of Giemsa stain, immunofluorescence assay and polymerase chain reaction
Shaheen Subhan,Roby J. Jose,Aparna Duggirala,Rajeswary Hari,P. V. Krishna,Sesha B. Reddy,Savitri Sharma +6 more
TL;DR: A combination of PCR and immunofluorescence assay appears to be the most suitable choice of tests for diagnosis of HSV-1 keratitis, while detection of MNGC by Giemsa staining procedure may give a presumptive diagnosis of suspected viral infection.
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Osteoprotegerin Deficiency Limits Angiotensin II–Induced Aortic Dilatation and Rupture in the Apolipoprotein E–Knockout Mouse
TL;DR: Findings support a role for osteoprotegerin in aortic aneurysm through upregulation of CTSS, matrix metalloproteinase 2, and matrix meetingallop Proteinase 9 within the aorta, promoting an inflammatory phenotype in aortsic vascular smooth muscle cells in response to angiotensin II.