Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents

A concise synthesis of heteroaryl dibenzopyranones 9a,b, 10a,b, 11a−c, and 12a−c has been achieved by the LDA-induced migration of heterobiaryl O-carbamates 18, 21, 25, and 30 which, in turn, were prepared in good yield using a combined directed ortho lithiation (DoM)−transition-metal-catalyzed Suzuki cross-coupling strategy. An efficient and general route to a wide variety of heterocycles including coumestans 19a,c and the previously unknown isothiocoumestan ring system 22b has been thereby achieved.

Combined directed ortho and remote metalation-Suzuki cross-coupling strategies. Efficient synthesis of heteroaryl-fused benzopyranones from biaryl O-carbamates.

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

Nanocrystalline CuFe2O4 catalyzed one pot three component synthesis of chromeno[4,3-b]pyrrol-4(1H)-one derivatives has been achieved in aqueous media. The reaction between the essential building blocks (amine, glyoxal monohydrate and 4-aminocoumarin) has been performed at low catalyst loading, leading to a high yield of the desired heterocyclic scaffold. CuFe2O4 magnetic nanoparticles were prepared by a simple and effective citric acid complex method and characterized by using XRD, FT-IR, EDX and TEM and HRTEM images. The easy recovery and reusability of the catalyst and operational simplicity of the process makes the protocol attractive, sustainable, and economic.

Facile and eco-friendly synthesis of chromeno[4,3-b]pyrrol-4(1H)-one derivatives applying magnetically recoverable nano crystalline CuFe2O4 involving a domino three-component reaction in aqueous media

A new application of polymer supported, homogeneous and reusable catalyst PEG–SO3H in the synthesis of coumarin and uracil fused pyrrole derivatives

Synthesis of [1]benzopyrano[4,3-b]pyrrol-4(1H)-ones from N(α)-(2-oxo-2H-1-benzopyran-4-yl)weinreb α-aminoamides

4-N-(Acylmethyl)aminocoumarins or their ketal derivatives were prepared from 4-chlorocoumarin and α-amino ketones (chlorohydrates or ketal derivatives) in ethanol/triethylamine media. Their subsequent treatment in acidic or basic media readily led to [1] benzopyrano[4,3-b]pyrrol-4(1H)-ones

Rocío Álvaro

Papers

Synthesis of [1]benzopyrano[4,3-b]pyrrol-4(1H)-ones from N(α)-(2-oxo-2H-1-benzopyran-4-yl)weinreb α-aminoamides

Synthesis of [1]Benzopyrano[4,3-b]pyrrol-4(1H)-ones from 4-Chlorocoumarin

Synthesis of [1]benzopyrano[2,3-b]pyrrol-4(1H)-ones

Synthesis of (1)Benzopyrano(4,3-b)pyrrol-4(1H)-ones from 4- Chlorocoumarin.

Synthesis of [1]Benzopyrano[2,3-b]pyrrol-4(1H)-ones.