(1990). Structure‐activity relationships of cytokinins. Critical Reviews in Plant Sciences: Vol. 9, No. 1, pp. 17-57.

Structure‐activity relationships of cytokinins

Publisher Summary This chapter discusses the potentials, limited successes, and limitations of tissue culture systems in screening for and against plant growth regulators. For a cell culture screening system to be useful, it must answer well-defined physiological questions that can be easily measured in the cultures, and it must parallel the physiological effect in the whole plant. Such screens should be for cell division- or morphogenesis-inducing factors, for specific types of biochemical production, or for source or sink activity enhancement. Plant cell cultures, when wisely used, can be powerful tools to screen for plant hormone activities, especially for cytokinins; screen for activities of some types of yield enhancers or of compounds that may alter assimilate partitioning; and screen for activity of natural and synthetic phytotoxic and phytostatic compounds such as herbicides, allelochemicals, and toxins from microorganisms. They can also be used to screen compounds for their ability to elicit resistance to herbicides and to microorganisms.

Plant Tissue Culture Systems for Screening of Plant Growth Regulators: Hormones, Herbicides, and Natural Phytotoxins

Binding study of novel anti-diabetic pyrimidine fused heterocycles to β-lactoglobulin as a carrier protein.

Effects of 4-alkylaminopteridines on tobacco callus growth

The structural properties of Hypoxanthine compound related to molecular dynamic activity have been ornately interpreted in this methodical research work. The FT-IR, FT-Raman, NMR and UV–Visible spectral analysis has been carried out and the obtained results were validated using theoretical tools. The tautomerism of the compound has been monitored while analyzing the molecular structure regarding to describe unknown properties and applications. The displacement of chemical shift of core carbons in pyrimidine and Imidazole rings by the injection of   O atom and the mechanism customized to induce chemical properties were interpreted. The electronic degeneracy pathway in the interaction orbitals was discussed by viewing the frontier molecular overlapping. The involvement of CT-complex transitions in non bonding molecular orbitals has been inspected. The QSAR properties, Ligand efficiency (LE), Lipophilic Efficiency (LipE), were calculated and reported for explaining biological activity of Hypoxanthine. The drug and biological activity of the present compound was interpreted and the capability of suitable applications has been interpreted. The VCD spectrum for the measurement of toxicity level was simulated and the rate of masking was examined.

Molecular structure investigation towards pharmacodynamic activity and QSAR analysis on hypoxanthine using experimental and computational tools

Studies on the structural specificity of kinetin have demonstrated that a variety of 6-(substituted)aminopurines and 6-(substituted)thiopurines, even with an additional 2-fluoro or 2-amino substituent, replace kinetin in several biological systems. It was of considerable interest to investigate further the specificity of the imidazole ring by preparing a group of 4-(substituted)pteridines. That the pteridine ring cannot replace the purine ring with retention of activity is indicated by the inactivity of these compounds in stimulating the rate of lettuce seed germination either in the presence or in the absence of gibberellic acid.

Rodney F. Lloyd

Papers

4-(Substituted)pteridines, analogues of kinetin

Isosteric relationship of biologically active N6-(ω-phenylalkyl) adenines and N6-(ω-1′,4′-cyclohexadien-1-ylalkyl)adenines☆