R
Roger C. Small
Researcher at University of Manchester
Publications - 65
Citations - 2059
Roger C. Small is an academic researcher from University of Manchester. The author has contributed to research in topics: Trachealis muscle & Cromakalim. The author has an hindex of 28, co-authored 65 publications receiving 2046 citations.
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Journal ArticleDOI
Electrical and mechanical effects of BRL34915 in guinea‐pig isolated trachealis
TL;DR: It is concluded that BRL34915 evokes relaxation of the trachealis by a mechanism that involves neither β‐adrenoceptor activation nor direct reduction of the sensitivity of the intracellular contractile machinery to cytosolic free Ca2+.
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Evidence that the mechanism of the inhibitory action of pinacidil in rat and guinea-pig smooth muscle differs from that of glyceryl trinitrate.
K.M. Bray,D. T. Newgreen,Roger C. Small,J. S. Southerton,S.G. Taylor,Sheila W. Weir,Arthur H. Weston +6 more
TL;DR: It is concluded that pinacidil and GTN do not share a common relaxant mechanism, and evidence has been obtained thatPinacidil exerts its inhibitory effects by the opening of apamin‐insensitive, 86Rb‐permeable K+ channels.
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Antagonism of Ca2+ and other actions of verapamil in guinea‐pig isolated trachealis
TL;DR: Verapamil (0.1 to 10 μmol l−1) was an effective antagonist of CaCl2 in trachealis bathed by a K+-rich, Ca2+-free physiological salt solution as discussed by the authors.
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The relaxant action of BRL 34915 in rat uterus.
M. Hollingsworth,T. Amédée,Diane Edwards,Jean Mironneau,Jean-Pierre Savineau,Roger C. Small,Arthur H. Weston +6 more
TL;DR: The results suggest that in the uterus the effects of BRL 34915 may be restricted to K+‐channels involved in the production of pacemaker activity.
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Evidence that the spasmogenic action of tetraethylammonium in guinea-pig trachealis is both direct and dependent on the cellular influx of calcium ion.
TL;DR: It is concluded that TEA acts directly on the smooth muscle of guinea‐pig trachea, that the spasm and electrical slow waves evoked are Ca2‐dependent and that the cellular influx of Ca2+ is increased.