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Roger L.H. Pobbe
Researcher at University of Hawaii
Publications - 23
Citations - 1411
Roger L.H. Pobbe is an academic researcher from University of Hawaii. The author has contributed to research in topics: Dorsal raphe nucleus & Anxiolytic. The author has an hindex of 16, co-authored 23 publications receiving 1235 citations. Previous affiliations of Roger L.H. Pobbe include University of São Paulo.
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Journal ArticleDOI
Risk assessment as an evolved threat detection and analysis process
TL;DR: Risk assessment behaviors respond to drugs effective against generalized anxiety disorder; however, flight, a dominant specific defense in many common situations, shows a pharmacological response profile closer to that of panic disorder.
Journal ArticleDOI
The BTBR T+ tf/J mouse model for autism spectrum disorders-in search of biomarkers.
Ksenia Z. Meyza,Erwin B. Defensor,Ashley L. Jensen,Michael J. Corley,Brandon L. Pearson,Roger L.H. Pobbe,Valerie J. Bolivar,D. Caroline Blanchard,Robert J. Blanchard +8 more
TL;DR: This review covers much of the data available to date on BTBR behavior, neuroanatomy and physiology in search for candidate biomarkers, which could both serve as diagnostic tools and help to design effective treatments for the behavioral symptoms of ASD.
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A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice.
Erwin B. Defensor,Brandon L. Pearson,Roger L.H. Pobbe,Valerie J. Bolivar,Valerie J. Bolivar,D. Caroline Blanchard,D. Caroline Blanchard,Robert J. Blanchard +7 more
TL;DR: The results demonstrated avoidance of reciprocal frontal orientations in the BTBR, providing a parallel to gaze aversion, a fundamental predictor of autism, and suggests that crawl under behavior, observed at high levels in BTBR mice, is elicited by the aversiveness of social proximity.
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Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors
Roger L.H. Pobbe,Brandon L. Pearson,Erwin B. Defensor,Valerie J. Bolivar,Valerie J. Bolivar,W. Scott Young,Heon-Jin Lee,D. Caroline Blanchard,D. Caroline Blanchard,Robert J. Blanchard +9 more
TL;DR: The present data indicate that the profile for Oxtr KO mice, including consistent social deficits, and reduced levels of communication, models multiple components of the ASD phenotype.
Journal ArticleDOI
Expression of social behaviors of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system.
Roger L.H. Pobbe,Brandon L. Pearson,Erwin B. Defensor,Valerie J. Bolivar,Valerie J. Bolivar,D. Caroline Blanchard,D. Caroline Blanchard,Robert J. Blanchard +7 more
TL;DR: The present data indicates that the strain profile for BTBR mice, including consistent social deficits and high levels of repetitive self-grooming, models multiple components of the ASD phenotype.