R
Roland K. Robins
Researcher at University of Utah
Publications - 601
Citations - 17538
Roland K. Robins is an academic researcher from University of Utah. The author has contributed to research in topics: Purine & Nucleoside. The author has an hindex of 62, co-authored 601 publications receiving 17226 citations. Previous affiliations of Roland K. Robins include Government of the United States of America & Kitasato University.
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Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics
TL;DR: Les valeurs d'hydrophobicite de 120 types d'atomes sont evalues pour 893 composes a partir des refractivites molaires de 538 composes and la methode de superposition a ete appliquee a des antibiotiques nucleosides naturels isabelle d'un nombre important de composes.
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Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.
Robert W. Sidwell,John H. Huffman,Gyaneshwar P. Khare,Lois B. Allen,Joseph T. Witkowski,Roland K. Robins +5 more
TL;DR: Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses and applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice.
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Mechanism of Action of 1-β-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole), A New Broad-Spectrum Antiviral Agent
David G. Streeter,Joseph T. Witkowski,Gyaneshwar P. Khare,Robert W. Sidwell,Randy J. Bauer,Roland K. Robins,Lionel N. Simon +6 more
TL;DR: Results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate, which would result in inhibition of the synthesis of vital viral nucleic acid.
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