R
Roland Löser
Publications - 11
Citations - 670
Roland Löser is an academic researcher. The author has contributed to research in topics: Antiestrogen & In vivo. The author has an hindex of 9, co-authored 11 publications receiving 660 citations.
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Journal Article
In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells
Katja Wosikowski,Elfi Biedermann,Benno Rattel,Norbert Breiter,Peter Jank,Roland Löser,Gerrit Jansen,Godefridus J. Peters +7 more
TL;DR: MTX-HSA is effectively taken up by the cells via albumin receptor- or folate receptor-mediated endocytosis and time-dependently released as an active compound into the cytosol to exert an inhibiting effect on TS and to induce cell cycle alterations.
Journal Article
Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.
TL;DR: This is the first report to describe a strong antiangiogenic potency of FK-866 in a murine renal cell carcinoma model (RENCA) and it has antitumoral and antimetastatic activity in RENCA mice.
Journal ArticleDOI
Polyethylene glycol conjugates of methotrexate varying in their molecular weight from MW 750 to MW 40000: synthesis, characterization, and structure-activity relationships in vitro and in vivo
Katja Riebeseel,Elfi Biedermann,Roland Löser,Norbert Breiter,Ralf Hanselmann,Rolf Mülhaupt,Clemens Unger,Felix Kratz +7 more
TL;DR: Results indicate that release of MTX from polymer conjugates is not necessary for an effective interaction with the active site of dihydrofolate reductase, and in vitro cytotoxicity revealed that the IC(50) values of the tested compounds increased with the size of the drug-polymer conjugate.
Journal Article
WK175, a Novel Antitumor Agent, Decreases the Intracellular Nicotinamide Adenine Dinucleotide Concentration and Induces the Apoptotic Cascade in Human Leukemia Cells
TL;DR: It is found that WK175 induces apoptotic cell death without any DNA-damaging effect, implying that decreased NAD(+) concentration initiates the apoptotic cascade, resulting in the antitumor effect of WK 175.
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Preclinical data for Droloxifene
TL;DR: Droloxifene may represent an important step forward in the treatment of mammary carcinomas in women through its better tolerability and increased efficacy compared with Tamoxifen, and may well be the safer choice for long-term adjuvant or preventive treatment of breast cancer.