Showing papers in "Cancer Letters in 1994"

TL;DR: It is suggested that steroid receptor and ER BB2-positive breast tumours are resistant to tamoxifen therapy and, supported by experimental evidence showing an oestrogen receptor dependent up-regulation of ERBB2 expression upon tamoxIFen administration, possibly even growth stimulated by the drug.

TL;DR: An interactive computer system evaluates and diagnoses based on cytologic features derived directly from a digital scan of fine-needle aspirate (FNA) slides and actual accuracy was 100%.

TL;DR: In vitro [3H]thymidine incorporation showed the inhibition of DNA synthesis in fibrosarcoma cells by the flavonoids, and Elevated levels of lipid peroxides, cytochrome P450 and decreased activity of glutathione-S-transferase (GST) were observed in the tumor bearing animals.

TL;DR: Investigation of the tumor suppressor gene p53 in precancerous actinic keratosis lesions and malignant squamous cell carcinomas suggests p53 mutations may be involved in the malignant conversion of AKs to SCCs and that p53 may be useful as a biomarker to study the potential modulatory effects of cancer chemopreventive agents against skin cancer.

TL;DR: Results indicate that 'Sho-saiko-to' includes potent antitumor components such as saikosaponin-a, -d, baicalin against human hepatoma cells as well as other human cell lines.

TL;DR: The field of butyrate-induced differentiation of neoplastic and non-neoplastic cells is reviewed and possible clinical correlations considered, and the concentrations required in vitro for biologic effect, and likely pharmacokinetic behavior in vivo are discussed.

TL;DR: The results suggest that GLA, EPA, and DHA are cytotoxic to both vincristine-sensitive and resistant human cervical carcinoma cells and that it is a free radical dependent process.

TL;DR: Results indicate that antioxidants, and GTC in particular, inhibit rat mammary gland carcinogenesis after DMBA initiation, and the average size of palpable mammary tumors was significantly smaller in the catechol, phytic acid and catechins groups.

TL;DR: Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.

TL;DR: Data suggest that curcumin may inhibit skin cancer through the modulation of expression of these proto-oncogenes in TPA-treated mouse skin in CD-1 mice.

TL;DR: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds inhibit diverse estrogen-induced responses in the rodent uterus and human breast cancer cells through antitumorigenic activity in female Sprague-Dawley rats.

TL;DR: The results provide the direct evidence for the antioxidant property of ECDs, and suggest that such an effect may contribute towards anticarcinogenic (specifically anti-skin tumor) promoting effects of green tea.

TL;DR: Results indicate that the PAPNET system could be a useful tool for both the screening and rescreening of cervical smears and has been shown to be sensitive to some types of abnormalities which have gone undetected during manual screening.

TL;DR: These methods provide an objective approach to neural network optimization and parameter selection applicable to other data bases of clinical and laboratory data.

TL;DR: It is reported that c-myc- or fosB-transformed rat embryonic fibroblast cells can be reverted by the introduction of the IRf-1 gene, suggesting the broad role of IRF-1 as a tumor suppressor.

TL;DR: The tea products represent another approach to lower the formation of HCAs, and are thought to be the genotoxic carcinogens associated with important types of human cancer in meat-eating populations, such as cancer of the breast, colon or pancreas.

TL;DR: It is suggested that p53 proteins accumulated by heat stress are associated with HSP72 and HSC73.

TL;DR: In this article, Thapsigargin (Tg), a non-phorbol ester type tumor promoter that specifically inhibits endoplasmic reticulum Ca(2+)-ATPase, transiently increased the level of cytosolic free calcium ([Ca2+]i] and subsequently induced chromatin condensation, nuclear fragmentation, and internucleosomal DNA cleavage in cultured PLC/PRF/5 human hepatoma cells.

TL;DR: Pathological examinations indicated that the incidence of large intestinal cancers occurring in Group 1 was 80%, significantly higher than that in Groups 2, 3 and 4 (p < 0.001), which might suggest that green tea has preventive effects on large intestinal cancer induction in spite of the different doses of catechin.

TL;DR: The cytotoxicity of quercetin is markedly higher in actively growing cells in comparison with confluent cells, and this effect was dose dependent and accompanied by a simultaneous inhibition of lactate release and a dramatic decrease of total cellular ATP content.

TL;DR: A significant increase in triglycerides and VLDL cholesterol and decreases in total, HDL and LDL cholesterol levels were demonstrated in patients with Stage IV disease when compared to those with Stage I breast cancer.

TL;DR: The increased VDR values in colonic tumors as compared with the normal adjacent tissues, may warrant the action of 1,25(OH)2D3 or its non-calcemic analogs, to help induce cell differentiation and growth inhibition in human colorectal cancer.

TL;DR: The data showing that chalcone has inhibitory effects against both pulmonary and mammary carcinogenesis when given after carcinogen administration provides the basis for further investigations of this and possibly other chalcones as chemopreventive suppressing agents.

TL;DR: Monitoring the temporal behavior of the hyperthermia is expected to substantially increase both the specificity of cancer detection and the likelihood of accurate diagnosis of breast cancer.

TL;DR: Eight patients with diffuse (non-operable) pre-cancerous lesions (oral lichen or leukoplakias) were treated with fenretinidec (4-HPR) applied topically twice daily and two patients had complete remission and the other six had a greater than 75% response.

TL;DR: The results indicate that the glutathione level of oral tissues may be a useful marker for oral cancer, which is in agreement with findings from lung squamous cell carcinoma, cervical squamous Cell carcinoma and other squamouscell carcinomas.

TL;DR: The results demonstrate the pro-oxidant properties of polyphenolic flavonoids, which are generally considered as antioxidants and anticarcinogens, suggesting their possible dual role in mutagenesis and carcinogenesis.

TL;DR: The relatively specific effect of genistein to inhibit tumor invasion suggests a role for tyrosine phosphorylation in this process, and may be effective inhibitors of tumor invasion and metastasis.

TL;DR: The AAV Rep78 gene product was able to down-regulate the human c-fos and c-myc proto-oncogene promoters in all three assay systems, which may partially explain AAVs anti-proliferation properties.

TL;DR: A computerized scheme for the classification of masses appearing on mammograms to reduce the number of false-positive diagnoses of malignancies and has the potential to effectively aid radiologists in determining appropriate patient management.