Ronald E. Unger

TL;DR: In SIVmac1A11, the vpr gene as well as the transmembrane domain of env are prematurely truncated, whereas the nef gene of Sivmac239 is prematurely truncation, and sequence differences are also noted in variable region 1 (V1) in the surface domain of the env gene.

TL;DR: Results indicate that differences in more than one region of the viral genome are responsible for the lack of virulence of SIVmac1A11.

TL;DR: No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.

TL;DR: It is concluded that gp130 env and one or more genetic elements are essential for a complete replication cycle of SIVmac in rhesus macaque macrophages but not sufficient for acomplete viral replication cycle in this cell type.

TL;DR: Analysis of RNA species initiated in the HIV-1 LTR supports the conclusion that cellular factors regulate the level of elongation of the transcription complex on the LTR, and evidence that in some cell types the predominant mechanism of transactivation by HIV- 1 TAT involves posttranscriptional processes is presented.