H
Hiroshi Kiyono
Researcher at University of Tokyo
Publications - 667
Citations - 37020
Hiroshi Kiyono is an academic researcher from University of Tokyo. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 98, co-authored 644 publications receiving 34181 citations. Previous affiliations of Hiroshi Kiyono include University of Cincinnati Academic Health Center & McMaster University.
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Journal ArticleDOI
The mucosal immune system : from fundamental concepts to vaccine development
Jerry R. McGhee,Jiri Mestecky,Mark T. Dertzbaugh,John H. Eldridge,Masatomo Hirasawa,Hiroshi Kiyono +5 more
TL;DR: Practical approaches for vaccine construction and delivery into mucosal inductive sites in an effort to elicit host protection at mucosal surfaces where the infection actually occurs are proposed.
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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
Satoshi Uematsu,Kosuke Fujimoto,Myoung Ho Jang,Bo-Gie Yang,Yun-Jae Jung,Mika Nishiyama,Shintaro Sato,Tohru Tsujimura,Masafumi Yamamoto,Yoshifumi Yokota,Hiroshi Kiyono,Masayuki Miyasaka,Ken Ishii,Shizuo Akira +13 more
TL;DR: These findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine and positively regulated the differentiation interleukin 17–producing T helper cells.
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NALT- versus PEYER'S-patch-mediated mucosal immunity
Hiroshi Kiyono,Satoshi Fukuyama +1 more
TL;DR: A greater understanding of the differences between NALT and other organized lymphoid tissues, such as Peyer's patches, should facilitate the development of nasal vaccines.
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Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria
Gregory F. Sonnenberg,Laurel A. Monticelli,Theresa Alenghat,Thomas C. Fung,Natalie A. Hutnick,Jun Kunisawa,Naoko Shibata,Stephanie Grunberg,Rohini Sinha,Adam M. Zahm,Mélanie R. Tardif,Taheri Sathaliyawala,Masaru Kubota,Donna L. Farber,Ronald G. Collman,Abraham Shaked,Lynette A. Fouser,David B. Weiner,Philippe A. Tessier,Joshua R. Friedman,Hiroshi Kiyono,Frederic D. Bushman,Kyong-Mi Chang,Kyong-Mi Chang,David Artis +24 more
TL;DR: It is shown that interleukin-22 (IL-22)–producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals, indicating that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases.
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Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Koji Hase,Kazuya Kawano,Tomonori Nochi,Gemilson Soares Pontes,Shinji Fukuda,Masashi Ebisawa,Kazunori Kadokura,Toru Tobe,Yumiko Fujimura,Sayaka Kawano,Atsuko Yabashi,Satoshi Waguri,Gaku Nakato,Shunsuke Kimura,Takaya Murakami,Mitsutoshi Iimura,Kimiyo Hamura,Shin Ichi Fukuoka,Anson W. Lowe,Kikuji Itoh,Hiroshi Kiyono,Hiroshi Ohno +21 more
TL;DR: GP2 is a previously unrecognized transcytotic receptor on M cells for type-I-piliated bacteria and is a prerequisite for the mucosal immune response to these bacteria, which could provide a new target for the development of M-cell-targeted mucosal vaccines.