Showing papers by "Ronald T. Burkman published in 2012"
Centers for Disease Control and Prevention1, Fred Hutchinson Cancer Research Center2, City of Hope National Medical Center3, Wayne State University4, University of Pennsylvania5, University of Southern California6, University of Oslo7, National Institutes of Health8, Tufts University9, George Washington University10
TL;DR: The data are reassuring in that, among women 35-64 years of age, there is no evidence that specific OC formulations increase breast cancer risk.
66 citations
TL;DR: The birth control pill celebrates its 50th birthday this year, as women and men celebrate five decades of this revolutionary method of family planning and the noncontraceptive health benefits that women experience beyond pregnancy prevention are discussed.
30 citations
TL;DR: This analysis suggests that HT use may modify the effect of variation in estrogen-related genes on breast cancer risk, which may affect Black and White women to a different extent.
Abstract: Racial differences in breast cancer risk, including the risks of hormone receptor subtypes of breast cancer, have been previously reported. We evaluated whether variation in genes related to estrogen metabolism (COMT, CYP1A1, CYP1B1, CYP17A1, CYP19A1, ESR1, GSTM1, GSTP1, GSTT1, HSD17B1, SULT1A1, and UGT1A1) contributes to breast cancer risk and/or racial differences in risk within the CARE study, a multi-centered, population-based case–control study of breast cancer. Genetic variation was assessed as single nucleotide polymorphisms (SNPs), haplotypes, and SNP–hormone therapy (HT) interactions within a subset of 1,644 cases and 1,451 controls, including 949 Black women (493 cases and 456 controls), sampled from the CARE study population. No appreciable associations with breast cancer risk were detected for single SNPs or haplotypes in women overall. We detected SNP–HT interactions in women overall within CYP1B1 (rs1800440; phet = 0.003) and within CYP17A1 (rs743572; phet = 0.009) in which never users of HT were at a decreased risk of breast cancer, while ever users were at a non-significant increased risk. When investigated among racial groups, we detected evidence of an SNP–HT interaction with CYP1B1 in White women (p value = 0.02) and with CYP17A1 in Black women (p value = 0.04). This analysis suggests that HT use may modify the effect of variation in estrogen-related genes on breast cancer risk, which may affect Black and White women to a different extent.
29 citations
24 citations
TL;DR: While BC sub types were associated with self-reported race, BC subtypes were not associated with percent African ancestry and these study results suggest that subtle differences in percent Africa ancestry are less important than the overall presence of African ancestry in relation to BC tumor characteristics.
Abstract: African American (AA) women have a higher mortality from breast cancer (BC) compared to European American (EA) women. This may be due to the higher proportion of AA women with tumors that are diagnosed at more advanced stages and are characterized as being estrogen receptor negative (ER−)/progesterone receptor negative (PR−). Our study sought to determine whether self-reported race and percent African ancestry were associated with BC tumor characteristics. In a multi-center, population-based case–control study of BC, we determined percent African ancestry using ancestry informative markers (AIM) among women self-reporting race as AA or Black. BC tumor characteristics were associated with self-reported race (including a 30 % reduction in ER+/PR+ tumors [95 % confidence interval [CI]: 0.6–0.9] and a 1.5-fold increased risk of high grade [95 % CI: 1.2–1.9] for AA women compared to EA women). AIMs among AA women were not associated with BC tumor characteristics (AA women with ≥95 % versus <80 % African ancestry, odds ratio [OR] = 1.0 for ER+/PR+ [95 % CI: 0.6–1.8] and OR = 0.9 for high-grade tumors [95 % CI: 0.6–1.4]). Similar findings were observed for BC stage. While BC subtypes were associated with self-reported race, BC subtypes were not associated with percent African ancestry. These study results suggest that subtle differences in percent African ancestry are less important than the overall presence of African ancestry in relation to BC tumor characteristics.
6 citations