Michael S. Simon

TL;DR: Most risks and benefits dissipated postintervention, although some elevation in breast cancer risk persisted during cumulative follow-up and the 2 WHI hormone therapy trials do not support use of this therapy.

TL;DR: Use of oral contraceptives by women with a family history of breast cancer was not associated with an increased risk of Breast cancer, nor was the initiation of oral-contraceptive use at a young age, among women from 35 to 64 years of age.

TL;DR: This long-term follow-up study of 2 placebo-controlled randomized clinical trials found prior randomized use of CEE alone, compared with placebo, among women who had a previous hysterectomy was significantly associated withLower breast cancer incidence and lower breast cancer mortality, whereas prior randomizedUse of Cee plus MPA, comparedWithplace, amongWomen who had an intact uterus, was significant associated with a higher breast cancers incidence but no significant difference in breast cancer deaths.

TL;DR: The findings, suggestive of diagnostic delay, do not support a clinically meaningful benefit for combined hormone therapy on colorectal cancer.

TL;DR: Data indicate that women in the Women's Health Initiative dietary change intervention made substantial changes in food choices, which can facilitate future low-fat interventions, and also offer clinical applications, by identifying foods that may be refractory to change.