Rosana Puccia

TL;DR: This study provides the first evidence for possible sexual reproduction in P. brasiliensis S1, but does not rule it out in the other two species.

TL;DR: Yeast forms of Paracoccidioides brasiliensis grown in liquid medium produced exocellular components which could be isolated in a pure form by gel filtration column chromatography or by Sepharose-patient immunoglobulin G affinity chromatography.

TL;DR: Describing and characterize RNA in EV preparations from the human pathogens Cryptococcus neoformans, Paracoccidiodes brasiliensis and Candida albicans, and from the model yeast Saccharomyces cerevisiae suggests that RNA-containing vesicles may be determinant for various biological processes, including cell communication and pathogenesis.

TL;DR: The results suggest the possible conservation of pathogenicity and virulence mechanisms among fungi, expand considerably gene identification in P. brasiliensis, and provide a broader basis for further progress in understanding its biological peculiarities.

TL;DR: Immunization of mice with both gp43 and P10 led to vigorous protection against intratracheal challenge by virulent P. brasiliensis, with a >200-fold decrease in lung CFU and halting of dissemination to the spleen and liver.