R
Rosemary A. Hoffman
Researcher at University of Pittsburgh
Publications - 140
Citations - 5462
Rosemary A. Hoffman is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Cytotoxic T cell & Transplantation. The author has an hindex of 39, co-authored 140 publications receiving 5205 citations. Previous affiliations of Rosemary A. Hoffman include United States Department of Veterans Affairs & Sichuan University.
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Journal ArticleDOI
Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.
Andreas K. Nussler,M. Di Silvio,Timothy R. Billiar,Rosemary A. Hoffman,David A. Geller,Rick Selby,Juan Madariaga,Richard L. Simmons +7 more
TL;DR: Evidence is provided for the existence of typical inducible NO biosynthesis in a human cell type after stimulation with interleukin 1, tumor necrosis factor, IFN- gamma, and endotoxin in freshly isolated human hepatocytes.
Journal ArticleDOI
Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells
Allan Tsung,Rosemary A. Hoffman,Kunihiko Izuishi,Nathan D. Critchlow,Atsunori Nakao,Meagan H. Chan,Michael T. Lotze,David A. Geller,Timothy R. Billiar +8 more
TL;DR: It is demonstrated that TLR4 engagement on actively phagocytic nonparenchymal cells such as Kupffer cells is required for warm I/R-induced injury and inflammation in the liver.
Journal Article
Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.
TL;DR: Inhibition of rat SPL proliferation to alloantigen seems not to be caused by the lack of production of cytokines able to induce T cell proliferation, or by an indirect deleterious effect on the mitochondrial respiration and viability of macrophages that oxidatively metabolize L-arginine.
Journal Article
Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.
Lien Lu,Clark A. Bonham,F G Chambers,Simon C. Watkins,Rosemary A. Hoffman,Richard L. Simmons,Angus W. Thomson +6 more
TL;DR: Although DC function initially as the most potent APCs for T cell activation, DC induced to synthesize NOS by IFN-gamma may inhibit (allogeneic) T cell proliferation: NO may suppress lymphocyte proliferation and also induce apoptosis of the most powerful source of alloantigenic stimulation.