R
Roshan Goswami
Publications - 6
Citations - 182
Roshan Goswami is an academic researcher. The author has contributed to research in topics: Drug delivery & Biology. The author has an hindex of 3, co-authored 3 publications receiving 119 citations.
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Development and characterization of surface modified PLGA nanoparticles for nasal vaccine delivery: effect of mucoadhesive coating on antigen uptake and immune adjuvant activity.
TL;DR: GC-PLGA NPs could be a promising carrier adjuvant for the nasal vaccine delivery for inducing a potent immune response at mucosal surface(s) and systemic circulation.
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Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines.
Roshan Goswami,Despo Chatzikleanthous,Gustavo Lou,Fabiola Giusti,Alessandra Bonci,Marianna Taccone,Michela Brazzoli,Simona Gallorini,Ilaria Ferlenghi,Francesco Berti,Derek T. O'Hagan,Carlo Pergola,Barbara Baudner,Roberto Adamo +13 more
TL;DR: The present work illustrates the benefit of mannosylation of LNPs to achieve a faster immune response with SAM vaccines and these observations could contribute to the development of novel skin delivery systems for SAM vaccines.
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Conjugation of Mannans to Enhance the Potency of Liposome Nanoparticles for the Delivery of RNA Vaccines
TL;DR: In this article, a set of mannosylated lipid nanoparticles (MLNPs) were modified with mannans of different lengths (from mono to tetrasaccharide), in order to study the effect on antibody response of model SAM replicon encoding for the respiratory syncytial virus fusion F protein.
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Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer
Gayatri Patel,Tejas Agnihotri,Manoj Gitte,Tanuja S. Shinde,Shyam Sudhakar Gomte,Roshan Goswami,Aakanchha Jain +6 more
TL;DR: Exosomes are nanosized bio vesicles formed when multivesicular bodies and the plasma membrane merge and discharge into bodily fluids, and have been implicated in varied diseases including cancer as mentioned in this paper .
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Improvement of monoclonal antibody stability by modulating trace metal iron concentration in cell culture media: a case study.
Stefano Colombo,Alicia Alonso,Rebeca Real,Roshan Goswami,Marissa Suarez,Samuel Ogueta,Margarida Almeida,Laxmi Adhikary,Mónica G. Malmierca,Ivan S de Melo +9 more
TL;DR: In this article , the authors explored the impact of iron content variability in the manufacturing cell culture media on drug substance purity and quality, and linked the effect of the iron content on antibody degradation by self-aggregation, methionine oxidation, and decreased stability under long-term conditions.