Ross D. Jones

TL;DR: An endoribonuclease-based feedforward controller is developed that can adapt the expression level of a gene of interest to significant resource loading in mammalian cells and is a general-purpose device for predictable, robust, and context-independent control of gene expression.

TL;DR: One-pot evaluation enabled by poly-transfection accelerates and simplifies the design of genetic systems, providing a new high-information strategy for interrogating biology.

TL;DR: Statistical analysis of miRNA secondary structure and fold change of expression in response to Drosha knockdown showed that absence of mismatches in the central region of the hairpin, 5 and 9-12 nt from the Drosha cutting site conferred decreased sensitivity to Dro Sha knockdown, suggesting that, when limiting, Drosha processes miRNAs without mismatches more efficiently than mismatched mi RNAs.

TL;DR: In this article, the authors describe control systems approaches for achieving context-aware devices that are robust to context effects, and then consider cell fate programing as a case study to explore the potential impact of contextaware devices for regenerative medicine applications.

TL;DR: Cellular oxidative status could alter the potency of artemisinin in killing cancer cells, and antioxidants would reduce, whereas pro-oxidants would enhance, cytotoxicity.