R
Rossana Sirabella
Researcher at University of Naples Federico II
Publications - 57
Citations - 2273
Rossana Sirabella is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Neuroprotection & Brain ischemia. The author has an hindex of 27, co-authored 53 publications receiving 2005 citations. Previous affiliations of Rossana Sirabella include Centre national de la recherche scientifique.
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Journal ArticleDOI
Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions.
Lucio Annunziato,Salvatore Amoroso,Anna Pannaccione,Mauro Cataldi,Giuseppe Pignataro,Angela D'Alessio,Rossana Sirabella,Agnese Secondo,Luigi Sibaud,G.F. Di Renzo +9 more
TL;DR: The data gathered support the conclusion that during oxidative stress in neuronal cells the production of ROS triggers a mechanism that, through the release of cytochrome c from mitochondria and caspase-3 activation, leads to apoptosis.
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Two Sodium/Calcium Exchanger Gene Products, NCX1 and NCX3, Play a Major Role in the Development of Permanent Focal Cerebral Ischemia
Giuseppe Pignataro,Rosaria Gala,Ornella Cuomo,Anna Tortiglione,Lucia Giaccio,Pasqualina Castaldo,Rossana Sirabella,Carmela Matrone,Adriana Canitano,Salvatore Amoroso,Gianfranco Di Renzo,Lucio Annunziato +11 more
TL;DR: The results of this study suggest that in the neuroprotective effect exerted by NCX during ischemic injury, the major role is prevalently exerted byNCX1 and NCX3 gene products.
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Targeted Disruption of Na+/Ca2+ Exchanger 3 (NCX3) Gene Leads to a Worsening of Ischemic Brain Damage
Pasquale Molinaro,Ornella Cuomo,Giuseppe Pignataro,Francesca Boscia,Rossana Sirabella,Anna Pannaccione,Agnese Secondo,Antonella Scorziello,Annagrazia Adornetto,Rosaria Gala,Davide Viggiano,Sophie Sokolow,André Herchuelz,Stéphane Schurmans,Gianfranco Di Renzo,Lucio Annunziato +15 more
TL;DR: It is reported that ncX3 gene suppression leads to a worsening of brain damage after focal ischemia and to a massive neuronal death in all the hippocampal fields of organotypic cultures as well as in cortical neurons from ncx3−/− mice exposed to OGD plus reoxygenation.
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BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential.
Agnese Secondo,Rosaria Ilaria Staiano,Antonella Scorziello,Rossana Sirabella,Francesca Boscia,Annagrazia Adornetto,Valeria Valsecchi,Pasquale Molinaro,Lorella M.T. Canzoniero,Gianfranco Di Renzo,Lucio Annunziato +10 more
TL;DR: Results indicate that the brain specifically expressed NCX3 isoform more significantly contributes to the maintenance of [Ca2+]i homeostasis during experimental conditions mimicking ischemia, thereby preventing mitochondrial delta psi collapses and cell death.
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Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism
Luigi Formisano,Natascia Guida,Valeria Valsecchi,Maria Cantile,Ornella Cuomo,Antonio Vinciguerra,Giusy Laudati,Giuseppe Pignataro,Rossana Sirabella,Gianfranco Di Renzo,Lucio Annunziato +10 more
TL;DR: It is demonstrated that NCX1 expression is regulated by the Sp3/REST/HDAC1/ HDAC2 complex in tMCAO and by thesp1/HIF-1/p300 complex in PC+tMCAo and that epigenetic intervention, by modulating the acetylation of ncx1-Br, may be a strategy for the development of innovative therapeutic intervention in stroke.