Rui Zeng

TL;DR: Renal abnormalities occurred in the majority of patients with COVID-19 pneumonia, and patients with renal involvement had higher overall mortality compared with those without renal involvement, and severity of pneumonia was the risk factor most commonly associated with lower odds of proteinuric or hematuric remission and recovery from AKI.

TL;DR: It is found that ferroptosis appeared in tubular epithelial cells of various human kidney diseases and the upregulation of tubular proferroptotic gene ACSL4 was correlated with renal function in patients with acute kidney tubular injury.

TL;DR: It is found that hAD-MSC treatment upregulated the expression of tubular Sox9, promoted tubular regeneration, attenuated AKI, and mitigated subsequent renal fibrosis, but these beneficial effects were abolished by a drug inhibiting the release of exosomes from hAD.

TL;DR: This article showed that probiotic Lactobacillus casei Zhang (L.casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis, alleviated kidney injury, and delayed its progression to CKD in mice.

TL;DR: Using small interfering RNA to knockdown biliverdin reductase, it is demonstrated that the enzyme associates with phosphorylated Akt and mediates the hypoxia-induced EMT phenotype through a PI3K/Akt-dependent pathway.