R
Ruth Michels
Researcher at Lovelace Respiratory Research Institute
Publications - 3
Citations - 1007
Ruth Michels is an academic researcher from Lovelace Respiratory Research Institute. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 2, co-authored 3 publications receiving 960 citations.
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Journal ArticleDOI
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
Steven A. Belinsky,Kristen J. Nikula,William A. Palmisano,Ruth Michels,Geno Saccomanno,Edward Gabrielson,Stephen B. Baylin,James G. Herman +7 more
TL;DR: In4a (p16) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including lung cancer, the leading cause of cancer-related deaths in the U.S..
Aberrant methylation of p16 INK4a is an early event in lung cancer and a potential biomarker for early diagnosis (p16 methylationysputumyNNKysquamous cell carcinoma)
Steven A. Belinsky,K Risten J. Nikula,William A. Palmisano,Ruth Michels,G Eno Saccomanno,Edward Gabrielson,B. Baylin,James G. Herman +7 more
TL;DR: These studies show for the first time that an epigenetic alteration, aberrant methylation of the p16 gene, can be an early event in lung cancer and may constitute a new biomarker for early detection and monitoring of prevention trials.
Journal ArticleDOI
Concurrent fluorescence in situ hybridization and immunocytochemistry for the detection of chromosome aberrations in exfoliated bronchial epithelial cells.
R E Neft,Minerva M. Murphy,Lauren A. Tierney,Steven A. Belinsky,Marshall W. Anderson,Geno Saccomanno,Ruth Michels,Susan Timm,Frank D. Gilliland,Richard E. Crowell,John F. Lechner +10 more
TL;DR: This procedure allowed the rapid identification of airway epithelial cells with numerical chromosome aberrations in this sample and could increase the sensitivity and specificity of sputum cytology as a laboratory diagnostic tool for the early detection of lung cancer.