R
Ryan E. Pester
Researcher at Massachusetts Institute of Technology
Publications - 2
Citations - 1312
Ryan E. Pester is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Carcinogenesis & Cell cycle checkpoint. The author has an hindex of 2, co-authored 2 publications receiving 1252 citations.
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Suppression of non-small cell lung tumor development by the let-7 microRNA family
Madhu S. Kumar,Stefan J. Erkeland,Ryan E. Pester,Cindy Y. Chen,Margaret S. Ebert,Phillip A. Sharp,Tyler Jacks +6 more
TL;DR: It is shown that let-7 functionally inhibits non-small cell tumor development and was more potent in lung cancer cell lines harboring oncogenic K-Ras mutations than in lines with other mutations.
Journal ArticleDOI
Dicer1 functions as a haploinsufficient tumor suppressor
Madhu S. Kumar,Ryan E. Pester,Cindy Y. Chen,Keara Michelle Lane,Christine Chin,Jun Lu,David G. Kirsch,Todd R. Golub,Todd R. Golub,Todd R. Golub,Tyler Jacks +10 more
TL;DR: Dicer1 may be an important haploinsufficient tumor suppressor gene and, furthermore, that other factors controlling miRNA biogenesis may also function in this manner.