R
Ryan L. Setten
Researcher at City of Hope National Medical Center
Publications - 9
Citations - 937
Ryan L. Setten is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Regulation of gene expression & Transcription factor. The author has an hindex of 5, co-authored 7 publications receiving 531 citations. Previous affiliations of Ryan L. Setten include University of California, San Diego & Beckman Research Institute.
Papers
More filters
Journal ArticleDOI
The current state and future directions of RNAi-based therapeutics.
TL;DR: This Review discusses key advances in the design and development of RNAi drugs leading up to this landmark achievement, the state of the current clinical pipeline and prospects for future advances, including novel RNAi pathway agents utilizing mechanisms beyond post-translational RNAi silencing.
Journal ArticleDOI
Open chromatin profiling in mice livers reveals unique chromatin variations induced by high fat diet.
Amy Leung,Brian W. Parks,Juan Du,Juan Du,Candi Trac,Ryan L. Setten,Yin Chen,Kevin Brown,Aldons J. Lusis,Rama Natarajan,Dustin E. Schones,Dustin E. Schones +11 more
TL;DR: It is demonstrated that high fat diet leads to chromatin remodeling in the livers of C57BL/6J mice, as compared with mice fed a control diet, and that these chromatin changes are associated with changes in gene expression.
Journal ArticleDOI
Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma
TL;DR: The pre-clinical development of the first saRNA drug to enter the clinic is described, referred to as MTL-CEBPA, which induces increased expression of the transcription factor CCAAT/enhancer-binding protein alpha, a tumour suppressor and critical regulator of hepatocyte function.
Journal ArticleDOI
G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors
TL;DR: It is indicated that H3K9me2 nucleation is established at specific sequences that have base composition similar to CGIs and that H2O and DNA methylation work synergistically to regulate chromatin accessibility.
Journal ArticleDOI
Delivery of RNA Therapeutics: The Great Endosomal Escape!
TL;DR: Before RNA therapeutics can achieve their ultimate clinical potential to treat widespread human disease, the rate-limiting delivery problem of endosomal escape must be solved in a clinically acceptable manner.