R
Ryan P. Owen
Researcher at University of California, San Francisco
Publications - 9
Citations - 1944
Ryan P. Owen is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Nucleoside & Nucleoside analogue. The author has an hindex of 7, co-authored 9 publications receiving 1834 citations.
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Journal ArticleDOI
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Yan Shu,Steven A. Sheardown,Chaline Brown,Ryan P. Owen,Shuzhong Zhang,Richard A. Castro,Alexandra G. Ianculescu,Lin Yue,Joan C. Lo,Esteban G. Burchard,Claire M. Brett,Kathleen M. Giacomini +11 more
TL;DR: The data indicate that OCT1 is important for metformin therapeutic action and that genetic variation in OCT1 may contribute to variation in response to the drug.
Journal ArticleDOI
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
Y Shu,Y Shu,Chaline Brown,Richard A. Castro,RJ Shi,Emil T. Lin,Ryan P. Owen,SA Sheardown,L Yue,Esteban G. Burchard,Claire M. Brett,Kathleen M. Giacomini +11 more
TL;DR: The studies suggest that OCT1 genotype is a determinant of metformin pharmacokinetics, possibly reflecting species differences in hepatic expression level of the transporter.
Journal ArticleDOI
The concentrative nucleoside transporter family, SLC28.
TL;DR: Nucleoside transporters in the SLC28 and SLC29 families play critical roles in nucleoside salvage pathways where they mediate the first step of nucleotide biosynthesis and work in concert to terminate adenosine signaling.
Journal ArticleDOI
Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations
Jennifer H. Gray,Lara M. Mangravite,Ryan P. Owen,Thomas J. Urban,Wendy Chan,Elaine J. Carlson,Conrad C. Huang,Michiko Kawamoto,Susan J. Johns,Douglas Stryke,Thomas E. Ferrin,Kathleen M. Giacomini +11 more
TL;DR: It is suggested that common genetic variants of CNT1 may contribute to variation in systemic and intracellular levels of anti-cancer nucleoside analogs.
Journal ArticleDOI
Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.
Ryan P. Owen,Jennifer H. Gray,Travis R. Taylor,Elaine J. Carlson,Conrad C. Huang,Michiko Kawamoto,Susan J. Johns,Doug Stryke,Thomas E. Ferrin,Kathleen M. Giacomini +9 more
TL;DR: DNA samples from an ethnically diverse population were screened, and 10 coding region variants of CNT2 were screened and six non-synonymous variants were identified, and all were able to transport guanosine, and the four variants examined showed no significant difference in ribavirin kinetics.