D
Doug Stryke
Researcher at University of California, San Francisco
Publications - 43
Citations - 5041
Doug Stryke is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gene & Nanopore sequencing. The author has an hindex of 26, co-authored 40 publications receiving 3882 citations. Previous affiliations of Doug Stryke include Yonsei University.
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Journal ArticleDOI
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis
Michael R. Wilson,Hannah A. Sample,Kelsey C. Zorn,Shaun Arevalo,Guixia Yu,John Neuhaus,Scot Federman,Doug Stryke,Benjamin Briggs,Charles Langelier,Amy C. Berger,Vanja C. Douglas,S. Andrew Josephson,Felicia C. Chow,Brent D. Fulton,Joseph L. DeRisi,Jeffrey M. Gelfand,Samia N. Naccache,Jeffrey M. Bender,Jennifer Dien Bard,Jamie A. Murkey,Magrit Carlson,Paul M. Vespa,Tara Vijayan,Paul R Allyn,Shelley Campeau,Romney M. Humphries,Jeffrey D. Klausner,Czarina Ganzon,Fatemeh Memar,Nicolle Anne Ocampo,Lara Zimmermann,Stuart H. Cohen,Christopher R. Polage,Roberta L. DeBiasi,Barbara Haller,Ronald H. Dallas,Gabriela Maron,Randall T. Hayden,Kevin Messacar,Samuel R. Dominguez,Steve Miller,Charles Y. Chiu +42 more
TL;DR: Routine microbiologic testing is often insufficient to detect all neuroinvasive pathogens, so metagenomic NGS of CSF obtained from patients with meningitis or encephalitis improved diagnosis of neurologic infections and provided actionable information in some cases.
Journal ArticleDOI
Rapid metagenomic identification of viral pathogens in clinical samples by real-time nanopore sequencing analysis
Alexander L. Greninger,Samia N. Naccache,Scot Federman,Guixia Yu,Placide Mbala,Vanessa Brès,Doug Stryke,Jerome Bouquet,Sneha Somasekar,Jeffrey M. Linnen,Roger Y. Dodd,Prime Mulembakani,Bradley S. Schneider,Jean-Jacques Muyembe-Tamfum,Susan L. Stramer,Charles Y. Chiu +15 more
TL;DR: Using nanopore sequencing, metagenomic detection of viral pathogens directly from clinical samples was performed within an unprecedented <6 hr sample-to-answer turnaround time, and in a timeframe amenable to actionable clinical and public health diagnostics.
Journal ArticleDOI
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Deanna L. Kroetz,Christiane Pauli-Magnus,Laura M. Hodges,Conrad C. Huang,Michiko Kawamoto,Susan J. Johns,Doug Stryke,Thomas E. Ferrin,Joseph DeYoung,Travis R. Taylor,Elaine J. Carlson,Ira Herskowitz,Kathleen M. Giacomini,Andrew G. Clark +13 more
TL;DR: This study represents a comprehensive analysis of ABCB1 nucleotide diversity and haplotype structure in different populations and illustrates the importance of haplotype considerations in characterizing the functional consequences ofABCB1 polymorphisms.
Journal ArticleDOI
A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study
Alexander L. Greninger,Samia N. Naccache,Kevin Messacar,Anna Clayton,Guixia Yu,Sneha Somasekar,Scot Federman,Doug Stryke,Christopher Anderson,Shigeo Yagi,Sharon Messenger,Debra A. Wadford,Dongxiang Xia,James Watt,Keith Van Haren,Samuel R. Dominguez,Carol A. Glaser,Grace M. Aldrovandi,Charles Y. Chiu +18 more
TL;DR: Findings strengthen the putative association between enterovirus D68 and acute flaccid myelitis and the contention that acute Flaccid Myelitis is a rare yet severe clinical manifestation of enterov virus D68 infection in susceptible hosts.
Journal ArticleDOI
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
Yan Shu,Maya K. Leabman,Bo Feng,Lara M. Mangravite,Conrad C. Huang,Doug Stryke,Michiko Kawamoto,Susan J. Johns,Joseph DeYoung,Elaine J. Carlson,Thomas E. Ferrin,Ira Herskowitz,Kathleen M. Giacomini +12 more
TL;DR: The results indicate that changes at evolutionarily conserved positions of OCT1 are strong predictors of decreased function and suggest that a combination of evolutionary conservation and chemical change might be a stronger predictor of function.