R
Ryszard J. Gryglewski
Researcher at Jagiellonian University
Publications - 94
Citations - 10730
Ryszard J. Gryglewski is an academic researcher from Jagiellonian University. The author has contributed to research in topics: Prostacyclin & Nitric oxide. The author has an hindex of 30, co-authored 94 publications receiving 10596 citations. Previous affiliations of Ryszard J. Gryglewski include Jagiellonian University Medical College & Wellcome Trust.
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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
TL;DR: A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
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Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
TL;DR: It is demonstrated that EDRF is protected from breakdown by superoxide dismutase (SOD) and Cu2+, but not by catalase, and is inactivated by Fe2+.
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Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides
TL;DR: It is concluded that a balance between formation by arterial walls of PGX which prevents platelet aggregation and release by blood platelets of prostaglandin endoperoxides which induce aggregation is of the utmost importance for the control of thrombus formation in vessels.
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A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation
TL;DR: Investigation of microsomes from arterial wall or fundus of stomach with platelet-rich plasma under various conditions shows that the enzyme which generates PGX can utilize endoperoxides liberated from platelets or added to the cuvette, thereby preventing, interrupting or reversing the process of platelet aggregation.
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Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig
TL;DR: It may be concluded that corticosteroids neither inhibit prostaglandin synthetase nor influence prostag landin transport through the membranes but they do impair the availability of the substrate for the enzyme.