R
Ryszard Korona
Researcher at Jagiellonian University
Publications - 48
Citations - 1572
Ryszard Korona is an academic researcher from Jagiellonian University. The author has contributed to research in topics: Gene & Epistasis. The author has an hindex of 22, co-authored 46 publications receiving 1490 citations. Previous affiliations of Ryszard Korona include Michigan State University & University of Massachusetts Amherst.
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Direct Estimate of the Mutation Rate and the Distribution of Fitness Effects in the Yeast Saccharomyces cerevisiae
TL;DR: Estimates of the rate and frequency distribution of deleterious effects were obtained for the first time by direct scoring and characterization of individual mutations by applying tetrad analysis to a large number of yeast clones.
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Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat.
TL;DR: This work describes the evolution of 18 bacterial populations founded from a single progenitor genotype and propagated separately for 1000 generations in two distinct environments, one physically unstructured (mass-action liquid) and the other structured (agar surfaces).
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Epistatic buffering of fitness loss in yeast double deletion strains
Lukasz Jasnos,Ryszard Korona +1 more
TL;DR: It is suggested that epistasis is likely to diminish the negative effects of mutations when the ability to produce biomass at high rates contributes significantly to fitness.
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Environmental stress and mutational load in diploid strains of the yeast Saccharomyces cerevisiae
TL;DR: The present experiment uses diploid strains of yeast in which mutations arise at high rates because a mismatch-repair protein is missing, which resulted in a number of new alleles that were in heterozygous loci that had no detectable effect on fitness when the environment was benign.
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Small fitness effects and weak genetic interactions between deleterious mutations in heterozygous loci of the yeast Saccharomyces cerevisiae.
TL;DR: It is suggested that most mutations tend to exhibit small and weakly interacting effects in heterozygous loci regardless of how harmful they are in haploids or homozygotes.