Ryuichi Takahata

TL;DR: A positive association between the serotonin 2A receptor gene (HTR2A) and schizophrenia was found, but not between schizophrenia and the serotonin 1A receptor genes, which would suggest that the DNA region with susceptibility to schizophrenia lies in the H TR2A on the long arm of chromosomes 13.

TL;DR: Increases in CSF levels of prostaglandins, especially that of PGD2, are correlated in rats with heightened propensity towards sleep and further with the depth of sleep under normal as well as SD conditions.

TL;DR: During the inhibition of sleep, the rats in general showed an activation of behavior with moderate elevation of brain temperature and a detectable increase in food and water intake, suggesting that the sleep-inhibited state of the rats was similar to the physiological state of wakefulness and that the inhibitory effect was not due to the general toxicity of selenium.

TL;DR: It is concluded that PGD2 is the most effective sleep promoter among the eicosanoids examined so far and alters the brain temperature significantly at the tested doses.

TL;DR: It is concluded that systemic administration of these PGD synthase inhibitors has a sleep-reducing potency.