Ryuichiro Suto

TL;DR: It is reported here that heat shock proteins (HSP), the most abundant and conserved mammalian molecules, constitute such an internal signal that provides a unified mechanism for response to internal and external stimuli.

TL;DR: It is shown that exogenous antigens chaperoned by a heat shockprotein can be channeled into the endogenous pathway, presented by MHC class I molecules, and recognized by CD8+ T lymphocytes, which provides a basis for the tumor-specific and virus-specific immunogenicity of cognate heat shock protein preparations and offer a mechanism for the classical phenomenon of cross-priming.

TL;DR: It is demonstrated that HSPs are CD8+ T cell response–eliciting adjuvants that are immunologically active, as tested by their ability to elicit antitumor immunity and specificCD8+ cytolytic T lymphocyte response.

TL;DR: The finding that adoptive transfer of CD4 and CD8-depleted MLTC spleen cells, obtained from anti-Lyt-2.2 (CD8) mAb-treated B6 mice that had rejected BALB RL male 1, resulted in rejection of BALBRL male 1 inoculated into B6 nu/nu mice confirmed the above notion.

TL;DR: In this article, the authors analyzed the surgical results achieved by video assisted neck surgery (VANS) in thyroid and parathyroid diseases in 87 patients with a mean age of 49 years.